II. Indications

  1. Control of minor bleeding (e.g. tongue Laceration) in patients with prolonged INR (e.g. Warfarin)
  2. Used in combination with gelatins

III. Mechanism

  1. Topical Hemostatic Agent
  2. Thrombin facilitates Fibrinogen conversion to fibrin in the formation of clot

IV. Preparations

  1. Bovine-derived thrombin (Thrombin-JMI)
    1. Contraindicated in cow allergies
  2. Human plasma-derived Thrombin (Evithrom)
  3. Recombinant human thrombin (rhThrombin)
  4. Topical Thrombin in Gelatin (Floseal)

V. References

  1. Berry in Schrage (2013) Topical Hemostatic Agents, Medscape Emedicine
  2. Peralta in Sanfrey (2013) Overview of Topical Hemostatic Agents and tissues adhesives used in the operating room, UpToDate, Wolters-Kluwer
  3. Achneck (2010) Ann Surg 251(2):217-28 [PubMed]

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