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Mycophenolate mofetil

Indications
1. Refractory Rheumatoid Arthritis
Mechanism
1. Mycophenolic acid (MPA) derivative
2. Reversibly inhibits inosine monophosphate dehydrogenase (IMPDH)
3. Primarily effects T Cell and B Cell proliferation and Antibody production
Dosing
1. Dose: 500-1000 mg twice daily
Adverse effects
1. Infection
2. Malignancy (e.g. skin cancer, Lymphoma)
3. Neutropenia
4. Gastrointestinal Bleeding
5. Nausea or Vomiting
Monitoring
1. PPD before starting therapy
2. Complete Blood Count
  1. Obtain baseline
  2. Obtain weekly for first month, twice monthly for next 2 months and then monthly

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This page was written by Scott Moses, MD. This page was last revised on 1/21/2008 3:42:26 PM. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.