Rheumatology Book

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Calcitonin

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  1. Indications: Osteoporosis
    1. Weak alternative for women not on Estrogen Replacement
    2. Painful osteoporotic Fracture
  2. Efficacy
    1. Not as effective as Estrogen Replacement
    2. Reduces vertebral Fractures 30-60% for >2 years
    3. Increases BMD of spine 3% in osteoporotic women
  3. Preparations
    1. Calcitonin-Salmon
      1. Dosing: 100 IU SQ/IM qd ($195/mo)
    2. Miacalcin
      1. Dosing: 200 IU (1 spray) intranasally qd ($50/mo)
  4. Precautions
    1. Anaphylaxis risk (use test dose in clinic)
  5. Adverse Effects
    1. Skin Flushing
    2. Skin rash
    3. Nausea
    4. Dizzy

Calcitonin (C0006668)

Definition (MSH)A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.
Definition (CSP)a peptide hormone secreted by the parafollicular cells of the thyroid gland in response to hypercalcemia, which lowers blood calcium and phosphate by promoting renal excretion; chemotherapy for Paget's disease and severe hypercalcemia.
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Hormone (T125)
MSHD002116
EnglishCalcitonin, Calcitonin agent, Calcitonin preparation, Calcitonin product, Calcitrin, CT - Calcitonin, thyrocalcitonin, Thyrocalcitonin preparation
Spanishagente con calcitonina, calcitonina, preparado de calcitonina, preparado de tirocalcitonina, tirocalcitonina
Parent ConceptsPolypeptide Hormones (C0312439), peptide hormone (C0597192), Neuropeptides (C0027895), Peptides (C0030956), [HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER (C0991612), Calcium regulating hormone (C0360589), Bone resorption inhibitor (C0521941), Peptide hormones and their metabolites and precursors (C0582246), Duplicate concept (C1274013), Drug allergen (C1320237)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, NDFRT, PDQ, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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