Nephrology Book

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Renal Tubular Acidosis

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  1. Pathophysiology
    1. Kidney unable to excrete daily acid load
    2. Results in Metabolic Acidosis
  2. Types
    1. Type I Renal Tubular Acidosis: Distal RTA (Classic RTA)
    2. Type II Renal Tubular Acidosis: Proximal RTA
    3. Type IV Renal Tubular Acidosis: Hyperkalemic RTA
  3. Labs
    1. Chemistry Panel
      1. Serum Chloride elevated
      2. Serum bicarbonate decreased
      3. Anion Gap normal
    2. Arterial Blood Gas (ABG)
      1. Non-Anion Gap Metabolic Acidosis
    3. Fractional Excretion of Bicarbonate
      1. FE-HCO3 <5%: Distal RTA
      2. FE-HCO3 >15%: Proximal RTA
        1. Assumes serum bicarbonate >20 meq/L

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