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Zaleplon

Aka: Zaleplon, Sonata
  1. Indication
    1. Insomnia
    2. Consider for early awakening in middle of night
  2. Mechanism
    1. Nonbenzodiazepine hypnotic agent
  3. Pharmacokinetics
    1. Half-Life: 1 hour
    2. Peak Onset: 30 minutes
    3. Duration
      1. Typically 4 hours, but may be as long as 6-8 hour
    4. Metabolized by CYP450 3A4
  4. Dosing
    1. Start: 5-10 mg PO at bedtime
    2. Elderly: 5 mg PO at bedtime
    3. Maximum: 20 mg PO at bedtime
  5. Adverse Effects
    1. See Nonbenzodiazepine hypnotic agent for common effects
    2. Altered color perception
  6. Advantages
    1. See Nonbenzodiazepine hypnotic agent
    2. Effective in middle of night awakening
      1. Can take mid-way through sleep period
  7. Disadvantages
    1. Expensive: $85 per month

Sonata (C0876170)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C085665
English Sonata, sonata, Lundbeck brand of zaleplon, Wyeth brand of zaleplon, Zelepion, AHP brand of zaleplon
Sources
Derived from the NIH UMLS (Unified Medical Language System)


zaleplon (C0251504)

Definition (NCI) A nonbenzodiazepine from the pyrazolopyrimidine class with hypnotic, sedative, anxiolytic, and muscle relaxant properties. Zaleplon interacts with the gamma-aminobutyric acid (GABA) -A receptor, thereby affecting the chloride channel ionophore complex and potentiating the inhibitory effects of GABA. In addition, zaleplon binds selectively to the brain omega-1 receptor situated on the alpha subunit of the GABA-A/chloride ion channel receptor complex and potentiates t-butyl-bicyclophosphorothionate (TBPS) binding.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C085665
SnomedCT 321187004, 116104009, 387012004
English Acetamide, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethyl-, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethylacetamide, zaleplon, zaleplon (medication), ZALEPLON, zaleplon [Chemical/Ingredient], Zaleplon (product), Zaleplon (substance), Zaleplon
Spanish Zaleplon, zaleplón (producto), zaleplón (sustancia), zaleplón
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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