II. Dosing

  1. Start: 50 mg PO qd for 3 days
  2. Next: 50 mg PO bid for 3 days
  3. Next: 100 PO qhs for 3 days
  4. Therapeutic dose: 150 PO qhs
  5. Maximum: 250 mg PO qhs

III. Pharmacokinetics

  1. Serum Half Life: 21 hours
  2. Therapeutic plasma level: 125 to 300

IV. Adverse effects

  1. See Tricyclic Antidepressants
  2. Much less adverse effects than tertiary amines
  3. Moderate adverse effects
    1. Orthostatic Hypotension
    2. Cardiac Arrhythmia

V. Precautions

  1. See Tricyclic Antidepressants
  2. Serious cardiotoxicity in overdosage

VI. Advantages

  1. Activating
  2. Inexpensive
  3. Attention Deficit Hyperactivity Disorder effect

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Cost: Medications

desipramine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
DESIPRAMINE 10 MG TABLET Generic $0.10 each
DESIPRAMINE 100 MG TABLET Generic $0.56 each
DESIPRAMINE 25 MG TABLET Generic $0.18 each
DESIPRAMINE 50 MG TABLET Generic $0.46 each