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NorpraminAka: Desipramine, Pertofrane

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  1. Dosing
    1. Start: 50 mg PO qd for 3 days
    2. Next: 50 mg PO bid for 3 days
    3. Next: 100 PO qhs for 3 days
    4. Therapeutic dose: 150 PO qhs
    5. Maximum: 250 mg PO qhs
  2. Pharmacokinetics
    1. Serum Half Life: 21 hours
    2. Therapeutic plasma level: 125 to 300
  3. Adverse effects
    1. See Tricyclic Antidepressants
    2. Much less adverse effects than tertiary amines
    3. Moderate adverse effects
      1. Orthostatic Hypotension
      2. Cardiac arrhythmia
  4. Precautions
    1. See Tricyclic Antidepressants
    2. Serious cardiotoxicity in overdosage
  5. Advantages
    1. Activating
    2. Inexpensive
    3. Attention Deficit Hyperactivity Disorder effect

Desipramine (C0011685)

Definition (MSH)A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Definition (CSP)tricyclic dibenzazepine compound that potentiates neurotransmission; desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport; this compound also possesses minor anticholingeric activity, through its affinity to muscarinic receptors.
Definition (NCI)An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative of the antidepressant. Desipramine enhances monoamine neurotransmission in certain areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD003891
EnglishDemethylimipramine, Desipramine, DESIPRAMINE PREPARATION, Desmethylimipramine
Spanishdesipramina
Parent ConceptsAminoacridines (C0002536), Antidepressive Agents, Tricyclic (C0003290), Azepines (C0004484), Dibenzazepines (C0012029), Antidepressive Agents (C0003289)
SourcesAOD, CSP, LNC, MSH, MTH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Pertofrane (C0031232)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD003891
EnglishNovartis Brand of Desipramine Hydrochloride, Pertofran, Pertofrane, Pertrofran
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)


Norpramin (C0701352)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD003891
EnglishAventis Behring Brand of Desipramine Hydrochloride, Aventis Brand of Desipramine Hydrochloride, Norpramin
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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