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Norpramin
Aka: Norpramin, Desipramine, Pertofrane- Dosing
- Start: 50 mg PO qd for 3 days
- Next: 50 mg PO bid for 3 days
- Next: 100 PO qhs for 3 days
- Therapeutic dose: 150 PO qhs
- Maximum: 250 mg PO qhs
- Pharmacokinetics
- Serum Half Life: 21 hours
- Therapeutic plasma level: 125 to 300
- Adverse effects
- See Tricyclic Antidepressants
- Much less adverse effects than tertiary amines
- Moderate adverse effects
- Orthostatic Hypotension
- Cardiac arrhythmia
- Precautions
- See Tricyclic Antidepressants
- Serious cardiotoxicity in overdosage
- Advantages
- Activating
- Inexpensive
- Attention Deficit Hyperactivity Disorder effect
| Medication Costs | ||
|---|---|---|
| Norpramin (on 2/9/2012 at DrugStore.com) | ||
| Norpramin 10mg Tablets | #60 for $71.27 | ($1.19/unit) |
| Norpramin 25mg Tablets | #60 for $86.39 | ($1.44/unit) |
| Norpramin 50mg Tablets | #60 for $161.99 | ($2.70/unit) |
| Norpramin 75mg Tablets | #60 for $205.18 | ($3.42/unit) |
| Norpramin 100mg Tablets | #30 for $134.99 | ($4.50/unit) |
| Norpramin 150mg Tablets | #30 for $194.40 | ($6.48/unit) |
| Desipramine HCl (on 2/9/2012 at DrugStore.com) | ||
| Desipramine HCl 10mg Tablets | #60 for $60.46 | ($1.01/unit) |
| Desipramine HCl 25mg Tablets | #60 for $74.99 | ($1.25/unit) |
| Desipramine HCl 50mg Tablets | #60 for $124.99 | ($2.08/unit) |
| Desipramine HCl 75mg Tablets | #60 for $166.00 | ($2.77/unit) |
| Desipramine HCl 100mg Tablets | #30 for $100.99 | ($3.37/unit) |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Desipramine (C0011685) |
|
|---|---|
| Definition (MSH) | A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors. |
| Definition (CSP) | tricyclic dibenzazepine compound that potentiates neurotransmission; desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport; this compound also possesses minor anticholingeric activity, through its affinity to muscarinic receptors. |
| Definition (NCI) | An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative of the antidepressant. Desipramine enhances monoamine neurotransmission in certain areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D003891 |
| SnomedCT | 33378002, 372705002 |
| English | Desipramine, Demethylimipramine, Desmethylimipramine, desipramine, 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-, desmethylimipramine, Desipramine [Chemical/Ingredient], Desipramine (product), Desipramine (substance), DESIPRAMINE |
| Swedish | Desipramin |
| Czech | desipramin |
| Finnish | Desipramiini |
| Russian | DEZIPRAMIN, DESMETILIMIPRAMIN, DEZIPRAMINGIDROKHLORID, ДЕЗИПРАМИН, ДЕЗИПРАМИНГИДРОХЛОРИД, ДЕСМЕТИЛИМИПРАМИН |
| Japanese | デシプラミン, デスメチルイミプラミン |
| Italian | Desmetilimipramina, Demetilimipramina, Desipramina |
| Croatian | DESIPRAMIN |
| Polish | Dezypramina |
| Spanish | desipramina (producto), desipramina (sustancia), desipramina, Desipramina, Desmetilimipramina |
| French | Désipramine |
| German | Desipramin, Desmethylimipramin |
| Portuguese | Desipramina, Desmetilimipramina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Pertofrane (C0031232) |
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|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D003891 |
| English | Pertofrane, Pertofran, Novartis Brand of Desipramine Hydrochloride, Pertrofran, Rhône Poulenc Rorer Brand of Desipramine Hydrochloride, Rhône-Poulenc Rorer Brand of Desipramine Hydrochloride |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Norpramin (C0701352) |
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|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D003891 |
| Croatian | NORPRAMIN |
| English | norpramin, Norpramin, Aventis Behring Brand of Desipramine Hydrochloride, Aventis Brand of Desipramine Hydrochloride |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |