II. Class

  1. Medium acting Benzodiazepine

III. Indication

IV. Background

  1. Weekly Cost: $6

V. Pharmacokinetics

  1. Onset: 20 minutes
  2. Duration: 6-8 hours
  3. Half-Life: 10-24 hours

VI. Dosing

  1. Dose: 1-2 mg PO qhs

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Cost: Medications

estazolam (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
ESTAZOLAM 1 MG TABLET Generic $0.47 each
ESTAZOLAM 2 MG TABLET Generic $0.58 each

Ontology: Estazolam (C0014892)

Definition (NCI) A triazolo-benzodiazepine with anxiolytic, anticonvulsant, hypnotic, and muscle relaxant properties. Estazolam binds to the gamma-aminobutyric acid (GABA) receptor at a site distinct from the inhibitory neurotransmitter GABA binding site in the limbic system of the central nervous system (CNS). This binding leads to an opening of the chloride channels, which allows the flow of chloride ions into the neuron, hyperpolarizes the neuronal membrane, inhibits neuronal firing, and leads to a decrease in neuronal excitability.
Definition (MSH) A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004949
SnomedCT 96235001, 371364001
LNC LP16131-2, MTHU004627
English Estazolam, 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-, 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine, sedatives estazolam, estazolam (medication), estazolam, ESTAZOLAM, Estazolam [Chemical/Ingredient], Estazolam (substance), Estazolam product (product), Estazolam product
Swedish Estazolam
Czech estazolam
Finnish Estatsolaami
Russian ESTAZOLAM, ЭСТАЗОЛАМ
Japanese エスタゾラム
Spanish estazolam, producto (producto), estazolam (producto), estazolam, producto, estazolam (sustancia), estazolam, Estazolam
Polish Estazolam
French Estazolam
German Estazolam
Italian Estazolam
Portuguese Estazolam

Ontology: ProSom (C0722865)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004949
English Prosom, prosom, ProSom, Abbott Brand of Estazolam