II. Class

  1. Medium acting Benzodiazepine

III. Indication

  1. Insomnia
    1. Short-term use only (up to 12 weeks)

IV. Dosing

  1. Adult: 1 to 2 mg orally at bedtime
  2. Elderly: 0.5 to 1 mg orally at bedtime

V. Safety

  1. Pregnancy Category X
  2. Avoid in Lactation
  3. Schedule IV Controlled Substance

VI. Pharmacokinetics

  1. Onset: 20 minutes
  2. Duration: 6-8 hours
  3. Half-Life: 10-24 hours
  4. Metabolites are minimally active

VII. Drug Interactions

  1. Strong CYP3A4 Inhibitors (e.g. Ketoconazole, Itraconazole)
    1. Avoid Estazolam with these agents

VIII. Adverse Effects

X. References

  1. (2019) Med Lett Drugs Ther 61(1578): 121-6
  2. (2020) Presc Lett, Resource #361206, Appropriate Use of Benzodiazepines
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 55
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

estazolam (on 9/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ESTAZOLAM 2 MG TABLET Generic $1.37 each