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CampralAka: Acamprosate

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  1. Indications
    1. Maintenance of Alcohol abstinence
  2. Contraindications
    1. Severe renal insufficiency (CrCl <30 ml/min)
    2. Advanced Cirrhosis
  3. Mechanism
    1. Balances GABA and glutamate neurotransmitters
      1. Blocks glutaminergic N-methyl-D-Aspartate receptors
      2. Activates GABA Type A receptors
    2. Reduces anxiety from abstinence
  4. Efficacy
    1. Reduces short and longterm relapse rates
  5. Dosing
    1. Campral 666 mg (two 333 mg tabs) PO three times daily
      1. Start with one three times daily
      2. Increase with one additional tablet daily each week
      3. Slow titration reduces gastrointestinal side effects
    2. Indications to decrease to 666 mg AM, 333 noon, 333 PM
      1. Weight <60 kg
      2. Renal insufficiency
        1. Creatinine Clearance <50 ml/min, but >30 ml/min
        2. Contraindicated if Creatinine Clearance <30 ml/min
  6. Drug interactions
    1. No interaction with Alcohol or Benzodiazepines
    2. No interaction with Disulfiram (Antabuse)
  7. Adverse effects
    1. Transient Diarrhea (10%)
  8. Disadvatages
    1. Cost: $125/month
  9. References
    1. Mason (2001) J Clin Psychiatry 62:42

acamprosate (C0284941)

Definition (CSP)calcium salt of N-acetylhomotaurine; an adjunct to psychotherapy in maintaining abstinence after alcohol withdrawal in patients with alcohol dependence.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC043877
Englishacamprosate, Acamprosate - chemical, acamprostate, AOTA, N-acetylhomotaurine
Spanishacamprosato, acamprosato - sustancia quimica
Parent ConceptsAlcohol Deterrents (C0001947), Taurine (C0039350), gamma-Aminobutyrate (C0178649), Amino Acids, Sulfur (C0002527), Drugs used to treat addiction (C1629845)
SourcesAOD, CSP, MSH, MTH, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Campral (C0592792)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC043877
EnglishAlphapharma brand of acamprosate calcium, AWD.pharma brand of acamprosate calcium, Campral, Campral EC, Lipha brand of acamprosate calcium, Merck brand of acamprosate calcium
SourcesCSP, MSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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