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CampralAka: Acamprosate
- Indications
- Maintenance of Alcohol abstinence
- Contraindications
- Mechanism
- Balances GABA and glutamate neurotransmitters
- Blocks glutaminergic N-methyl-D-Aspartate receptors
- Activates GABA Type A receptors
- Reduces anxiety from abstinence
- Balances GABA and glutamate neurotransmitters
- Efficacy
- Reduces short and longterm relapse rates
- Dosing
- Campral 666 mg (two 333 mg tabs) PO three times daily
- Start with one three times daily
- Increase with one additional tablet daily each week
- Slow titration reduces gastrointestinal side effects
- Indications to decrease to 666 mg AM, 333 noon, 333 PM
- Weight <60 kg
- Renal insufficiency
- Creatinine Clearance <50 ml/min, but >30 ml/min
- Contraindicated if Creatinine Clearance <30 ml/min
- Campral 666 mg (two 333 mg tabs) PO three times daily
- Drug interactions
- No interaction with Alcohol or Benzodiazepines
- No interaction with Disulfiram (Antabuse)
- Adverse effects
- Transient Diarrhea (10%)
- Disadvatages
- Cost: $125/month
- References
acamprosate (C0284941) | |
|---|---|
| Definition (CSP) | calcium salt of N-acetylhomotaurine; an adjunct to psychotherapy in maintaining abstinence after alcohol withdrawal in patients with alcohol dependence. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | C043877 |
| English | acamprosate, Acamprosate - chemical, acamprostate, AOTA, N-acetylhomotaurine |
| Spanish | acamprosato, acamprosato - sustancia quimica |
| Parent Concepts | Alcohol Deterrents (C0001947), Taurine (C0039350), gamma-Aminobutyrate (C0178649), Amino Acids, Sulfur (C0002527), Drugs used to treat addiction (C1629845) |
| Sources | AOD, CSP, MSH, MTH, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
Campral (C0592792) | |
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | C043877 |
| English | Alphapharma brand of acamprosate calcium, AWD.pharma brand of acamprosate calcium, Campral, Campral EC, Lipha brand of acamprosate calcium, Merck brand of acamprosate calcium |
| Sources | CSP, MSH, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |