II. Definition

  1. Definitive, second trimester Antenatal Screening for fetal chromosomal abnormalities

III. Indications

  1. Antenatal Screening for fetal chromosomal abnormalities for high risk pregnancies

IV. Protocol

  1. Timing
    1. Safest time period: 16-18 weeks gestation
    2. Range of sampling time: 14-20 weeks gestation
  2. Technique
    1. Amniotic fluid sampled transabdominally under Ultrasound guidance

V. Adverse Effects

  1. Pregnancy loss (0.3 to 1% risk)
  2. Vaginal spotting
  3. Amniotic fluid leak
  4. Chorioamnionitis
  5. Fetal injury from Amniocentesis needle
  6. Failed procedure in which fetal cells in amniotic fluid do not grow in culture

VI. Efficacy: Down Syndrome detection

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Ontology: Amniocentesis (C0002627)

Definition (NCI) A prenatal diagnostic procedure in which a small sample of amniotic fluid is removed from the uterus by a needle inserted into the abdomen. This procedure is used to detect various genetic abnormalities in the fetus and/or the sex of the fetus.
Definition (MSH) Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.
Definition (CSP) percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid; it is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.
Concepts Diagnostic Procedure (T060)
MSH D000649
ICD9 75.1
ICD10 16600-00
SnomedCT 150019004, 177113002, 34536000, 265635006
CPT 59000, 1008945
LNC LP31595-9
English Amniocenteses, Amniocentesis, AMNIOCENTESIS DIAGNOSTIC, amniocentesis procedure, amniotic fluid test (AFT), amniocenteses, Amniocentesis diagnostic, AMNIOCENTESIS DIAGNOSIC, Amniocentesis; diagnostic, amniocentesis (procedure), amniocentesis, diagnostic amniocentesis (procedure), diagnostic amniocentesis, Incision and drainage of amnion, Diagnostic amniocentesis, AC - Amniocentesis, Diagnostic amniocentesis (procedure), Amniocentesis (procedure), Amniocentesis, NOS
Japanese 羊水穿刺, ヨウスイセンシ
Swedish Fostervattenprov
Czech amniocentéza, Amniocentéza
Finnish Lapsivesipisto
Russian AMNIOTSENTEZ, АМНИОЦЕНТЕЗ
Croatian AMNIOCENTEZA
Polish Nakłucie pęcherza płodowego, Amniopunkcja, Amniocenteza
Hungarian Amniocentesis
Norwegian Fostervannsprøve, Amniocentese
Spanish amniocentesis, amniocentesis (procedimiento), amniocentesis diagnóstica (procedimiento), amniocentesis diagnóstica, amniocentesis, SAI, incisión y drenaje del amnios, Amniocentesis
Dutch vruchtwaterpunctie, Amniocentese
French Amniocentèse
German Amnionpunktion, Amniozentese, Fruchtblasenpunktion
Italian Amniocentesi
Portuguese Amniocentese