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Labor SedationAka: Latent Labor Anesthesia

Intrapartum Analgesia (Use with Sedation medications)
1. Morphine Sulfate
  1. Intravenous: 2-4 mg
  2. Intramuscular: 10-15 mg
2. Meperidine (Demerol)
  1. Dosing
    1. Intravenous: 25-50 mg
    2. Intramuscular: 50-75 mg
  2. Precautions: Not recommended
    1. No benefits in First Stage of Labor
    2. Associated with higher rate of newborn distress
    3. Sosa (2004) Am J Obstet Gynecol 191:1212
Sedation in latent phase: Phenothiazine
1. General
  1. Less risk of neonatal depression except high dose
2. Preparations
  1. Hydroxyzine (Vistaril)
    1. Oral: 100 mg PO qhs prn
    2. Intramuscular: 50-100 mg
    3. Intravenous: 50 mg IV
  2. Promethazine (Phenergan)
    1. Oral, Intramuscular, or rectally: 25 to 50 mg
    2. Intravenous (not FDA approved): 12.5 to 25 mg
Sedation in latent phase: Barbiturates
1. Not recommended
2. Secobarbital (Seconal) 100 mg PO or IM
  1. Risk of neonatal depression (potentiated by Opioid)
  2. No known antagonist

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.