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Cystic Fibrosis in Pregnancy

See Also
1. Cystic Fibrosis
Epidemiology
1. No increase in fetal malformations noted
Management
1. Pregnancy
  1. Most antibiotics may be used
    1. Avoid Tetracyclines
    2. Quinolones are not Teratogenic
  2. Beta adrenergic agonists may be used
2. Delivery
  1. Avoid general anesthesia and Narcotics
  2. Epidural Anesthesia is preferred for analgesia
  3. Avoid prolonged labor (maternal exhaustion)
3. Lactation
  1. Healthy mothers with Cystic Fibrosis may breast feed
  2. Breast milk does not contain excess sodium
  3. Essential fatty acids and fat content is lower
Complications
1. Low weight gain in pregnancy
2. Cystic Fibrosis exacerbation
3. Preterm delivery rate: 6 to 35%
Prognosis
1. Factors associated with best pregnancy outcomes
  1. FEV1 >80%
  2. No Burkholderia cepacia colonization
2. Factors predicting pregnancy complications
  1. Pulmonary Hypertension
  2. Cor Pulmonale
  3. FEV1 <50%
References
1. Liaschko (2002) Can Fam Physician 48:463
2. (2002) Am Fam Physician 65(12):2583

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.