II. Mechanism

  1. Vinca alkaloids
    1. Inhibits mitosis (metaphase arrest)
    2. Cause disassembly of microtubules
  2. Podophyllotoxins
    1. Block cells in S-G2 phase of cell cycle
    2. DNA degradation
    3. Nucleoside transport inhibition
    4. Mitochondrial electron transport inhibition

III. Agents

  1. Periwinkle Plant (Vinca rosea) derivative
    1. Vinblastine (Velban)
    2. Vincristine (Oncovin)
  2. Mayapple plant (Podophyllum peltatum) derivative
    1. Etoposide (VP-16)
    2. Teniposide (VM-26)

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