II. Indication

  1. Genital Warts (home application)

III. Contraindications

  1. Not recommended for mucosal lesions
    1. Avoid on perianal, rectal, Urethral, vaginal warts

IV. Background

  1. Purified form of Podophyllotoxin extract

V. Mechanism

  1. Stops division of infected cells

VI. Preparation

  1. Podofilox (Condylox) 0.5% solution or gel
    1. Apply solution with cotton swab
    2. Apply Gel with finger (easier to apply)

VII. Technique

  1. Cycle application
    1. Apply twice daily for 3 days
    2. Wait 4 days, then restart application cycle
  2. Repeat cycle for up to 4 weekly cycles (maximum 10 cm^2)

VIII. Advantages

  1. Less irritating and as effective than Podophyllin
  2. Can use in conjunction with other methods

IX. Precautions

  1. Allow to dry before moving around
  2. Do not wash off
  3. Do not exceed 0.5 ml per day

X. Efficacy

  1. Works best on moist mucosal skin sites
  2. Does not work on keratinized Epidermis
  3. Similar efficacy to Imiquimod
    1. Complete clearance of Genital Warts in 45-77% with a 4-33% recurrence rate
    2. Buck (2006) Clin Evid (15): 2149-61 [PubMed]

XI. Safety

  1. Pregnancy Category C

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Related Studies

Cost: Medications

condylox (on 1/19/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CONDYLOX 0.5% GEL $173.30 per gram
podofilox (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PODOFILOX 0.5% TOPICAL SOLN Generic $12.95 per ml