Dermatology Book

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Podophyllotoxin

Aka: Podophyllotoxin, Condylox, Podofilox
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  1. Indication
    1. Home application for Genital Warts
  2. Contraindications
    1. Not recommended for mucosal lesions
      1. Avoid on perianal, rectal, Urethral, vaginal warts
  3. Preparation
    1. Purified form of Podophyllotoxin extract
    2. Podofilox (Condylox) 0.5% solution or gel
      1. Apply solution with cotton swab
      2. Apply Gel with finger (easier to apply)
  4. Advantages
    1. Less irritating and as effective than Podophyllin
    2. Can use in conjunction with other methods
  5. Technique
    1. Cycle application
    2. Apply bid for 3 days
    3. Wait 1-3 days, then restart application cycle
    4. Repeat cycle for up to 4 cycles (maximum 10 cm^2)
  6. Precautions
    1. Allow to dry before moving around
    2. Do not wash off
    3. Do not exceed 0.5 ml per day
  7. Efficacy
    1. Works best on moist mucosal skin sites
    2. Does not work on keratinized Epidermis
Medication Costs
Condylox (on 2/9/2012 at DrugStore.com)
Condylox 0.5% Gel 3.5gm Tube #1 for $357.00 ($357.00/unit)
Condylox 0.5% Solution 3.5ml Bottle #1 for $147.34 ($147.34/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

podofilox (C0032334)

Definition (MSH) A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Definition (NCI) A pure, stabilized form of podophyllin, in which only the biologically active portion of the compound is present. Podophyllotoxin is a toxic, polycyclic antimitotic agent isolated primarily from the rhizome of the plant Podophyllum peltatum. This agent is formulated for topical applications. (NCI04)
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D011034
SnomedCT 415127005, 76575003, 108931008, 415128000, 7959004
English Podofilox, Podophyllotoxin, Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9alpha))-, Podofilox preparation (product), Podofilox (substance), Podofilox preparation, PODOFILOX, podofilox (medication), podofilox, Podophyllotoxin [Chemical/Ingredient], podophyllotoxin, Podophyllotoxin (substance), Podophyllotoxin product, Podophyllotoxin product (product)
Swedish Podofyllotoxin
Spanish preparación con podofilotoxina, preparación con podofilox, preparación con podofilox (producto), podofilox, podofilox (sustancia), producto con podofilotoxina (producto), podofilotoxina (producto), producto con podofilotoxina, podofilotoxina (sustancia), podofilotoxina, Podofilotoxina
Czech podofylotoxin
Finnish Podofyllotoksiini
Russian PODOFILLOTOKSIN, EPIPODOFILLOTOKSIN, ПОДОФИЛЛОТОКСИН, ЭПИПОДОФИЛЛОТОКСИН
Japanese ポドフィロックス, ポドフィロトキシン, エピポドフィロトキシン
Italian Podofilox, Podofillotossina
Polish Podofilotoksyna
French Épipodophyllotoxine, Podophyllotoxine
German Podophyllotoxin
Portuguese Podofilotoxina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Condylox (C0700937)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131)
MSH D011034
English condylox, Condylox, Oclassen Brand of Podophyllotoxin, Wolff Brand of Podophyllotoxin
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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