II. Mechanism
III. Indications
IV. General
- Rectal forms are preferred for Proctitis
- Use oral and rectal forms combined for better results where pancolitis is present
V. Dosing: Ulcerative Colitis
- Oral
- Active disease: 2.4 to 4.8 grams/day divided 3 times daily
- Maintenance: 1.2 to 2.4 grams/day divided 3 times daily
- Suppository
- Active disease: 1000 mg once daily
- Maintenance: 500 mg once to twice daily
- Enema
- Active disease: 1 to 4 grams daily
- Maintenance: 2-4 grams daily to every third day
VI. Dosing: General
- Oral
- Asacol 800 mg orally three times daily
- Pentasa 1000 mg orally four times daily
- Mesalamine MMX (e.g. Lialda) 1200 mg orally twice daily (up to 2-4 tabs orally once daily or in divided dosing)
- Apriso 1.5 grams orally every morning
- Balsalazide Disodium (Giazo, Colazal) 750 mg orally three times daily
- Rectal (Provides high distal colon concentrations)
- Rowasa 500 mg suppository per Rectum twice daily
- Rowasa 4g in 60 ml Enema at bedtime
- Canasa 1000 mg rectal suppository at bedtime
VII. Adverse Effects
- Interstitial Nephritis
- Suppositories and enemas may cause rectal irritation
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Related Studies
mesalamine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
MESALAMINE 1,000 MG SUPP | Generic | $2.21 each |
MESALAMINE 4 GM/60 ML ENEMA | Generic | $0.13 per ml |
MESALAMINE 4 GM/60 ML KIT | Generic | $116.13 each |
MESALAMINE 800 MG DR TABLET | Generic | $5.99 each |
MESALAMINE DR 1.2 GM TABLET | Generic | $2.19 each |
MESALAMINE DR 400 MG CAPSULE | Generic | $2.53 each |
MESALAMINE ER 0.375 GRAM CAP | Generic | $0.89 each |
MESALAMINE ER 500 MG CAPSULE | Generic | $4.64 each |
pentasa (on 2/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
PENTASA 250 MG CAPSULE | $2.91 each | |
PENTASA 500 MG CAPSULE | Generic | $4.64 each |
lialda (on 6/14/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
LIALDA DR 1.2 GM TABLET | Generic | $2.05 each |
delzicol (on 7/19/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
DELZICOL DR 400 MG CAPSULE | Generic | $2.11 each |
balsalazide disodium (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
BALSALAZIDE DISODIUM 750 MG CP | Generic | $0.42 each |