Gastroenterology Book

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Sulfa-free 5-Aminosalacylic acidAka: Sulfa-free 5-ASA, Mesalamine, Asacol, Pentasa, Rowasa, Lialda

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  1. Mechanism
    1. 5-Aminosalicylic Acid Derivative
  2. Indications
    1. Inflammatory Bowel Disease
  3. General
    1. Rectal forms are preferred for proctitis
    2. Use oral and rectal forms combined for better results where pancolitis is present
  4. Dosing
    1. Oral
      1. Asacol 800 mg PO tid
      2. Pentasa 1000 mg PO qid
      3. Lialda 1200 mg, 2-4 tabs PO once daily
    2. Rectal (Provides high distal colon concentrations)
      1. Rowasa 500 mg suppository PR bid
      2. Rowasa 4g in 60 ml Enema qhs

mesalamine (C0127615)

Definition (MSH)An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
Definition (NCI)An agent derived from sulfasalazine, an antiinflammatory agent. Mesalamine may reduce inflammation through inhibition of cyclooxygenase and prostaglandin production. Following rectal or oral administration, only a small amount of mesalamine is absorbed; the remainder, acting topically, reduces bowel inflammation, diarrhea, rectal bleeding and stomach pain. (NCI04)
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
English5 Aminosalicylic Acid, Fisalamine, m Aminosalicylic Acid, mesalamine, MESALAMINE PREPARATION, Mesalamine product, Mesalazine, Mesalazine duplicate deleted, meta Aminosalicylic Acid
Spanishfisalamina, mesalamina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Pentasa (C0678171)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
EnglishAllphar Brand of Mesalamine, Ferring Brand of Mesalamine, Pentasa, Yamanouchi Brand of Mesalamine
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Asacol (C0678172)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
EnglishAsacol, Byk Brand of Mesalamine, Procter & Gamble Brand of Mesalamine
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Rowasa (C0699623)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
EnglishRowasa, Solvay Brand of Mesalamine
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Lialda (C1873792)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
EnglishLialda
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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