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LoperamideAka: Imodium
- Indications
- Traveler's Diarrhea
- Dosing
- Initial: 4 mg PO for single first dose
- Titrate: 2 mg PO after each loose stool
- Maximum: 16 mg/day
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| Definition (MSH) | One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally. |
| Definition (NCI) | A synthetic agent chemically related to the opiates with anti-diarrheal properties. Loperamide decreases gastro-intestinal motility by effects on the circular and longitudinal muscles of the intestine. Part of its anti-diarrheal effect may be due to a reduction of gastro-intestinal secretion produced by opioid receptor binding in the intestinal mucosa. (NCI04) |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Loperamide, LOPERAMIDE PREPARATION |
| Spanish | loperamida |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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