Gastroenterology Book

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Gamma glutamyl transferaseAka: GGT

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  1. See Also
    1. Liver Function Test
    2. Liver Function Test Abnormality
  2. Pathophysiology
    1. Membrane bound hepatic cell marker
    2. Suggests cholestasis
    3. Most sensitive, but least specific of all LFTs
  3. Normal: 0-30 U/L
  4. Increased (Elevation 3 times normal is significant)
    1. Chronic Alcoholic Hepatitis or other liver disease
    2. Liver neoplasm or metastases
    3. Nephrotic Syndrome
    4. Cholestasis
    5. Pancreatic Carcinoma
    6. Congestive Heart Failure (CHF)
    7. Sepsis
    8. Systemic Lupus Erythematosus (SLE)
    9. Medications
      1. Phenytoin
      2. Barbiturates

Gamma-glutamyl transferase (C0017040)

Definition (MSH)An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
Definition (NCI)GGT participates in the transfer of amino acids across the cellular membrane and in glutathione metabolism. High concentrations are found in the liver, bile ducts, and the kidney. A test that measures the amount of GGT in the blood is used to detect diseases of the liver, bile ducts, and kidney; and to differentiate liver or bile duct (hepatobiliary) disorders from bone disease.
ConceptsAmino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSHD005723
Englishgamma glutamyl transferase, gamma Glutamyl Transpeptidase, gamma glutamyltransferase, gamma glutamyltranspeptidase, gamma GTP, Gamma-glutamyl transferase, gamma-Glutamyl Transpeptidase, gamma-Glutamyltransferase, Gamma-GT, gammaglutamyltransferase, GGT, GGT - Gamma-glutamyl transferase, GGTP, Glutamyl Transpeptidase
Spanishgamma - glutamiltransferasa, glutamil transpeptidasa
Parent ConceptsAcyltransferase (C0001390), aminoacyltransferase (C0524998), Transferase (C0040676), Liver enzyme (C0443764), Glutamyl transferase (C0678107)
SourcesAOD, CSP, LNC, MSH, MTH, NCI, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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