Gastroenterology Book

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Carcinoembryonic AntigenAka: CEA

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  1. See Also
    1. Tumor Marker
  2. Indications
    1. Stage II or III (Duke B1-C1) Colon Cancer monitoring
    2. Do not use to screen for Colon Cancer or other cancer
  3. Interpretation
    1. Normal
      1. Non-smokers: <2.5 mg/ml
      2. Smokers: <5 ng/ml
    2. Increased
      1. Benign disease unlikely if >10 ng/ml
      2. Distant metastasis most likely if >100 ng/ml
  4. Efficacy
    1. Not specific
      1. Seen in other adenocarcinoma (see below)
    2. Sensitivity varies by tumor stage and differentiation
      1. CEA not increased in poorly differentiated tumors
      2. Increased in <25% of Duke A or B stage Colon Cancer
      3. Increased in 50% with Duke C stage Colon Cancer
      4. Increased in 75% of Duke D stage Colon Cancer
  5. Causes of increased CEA
    1. Benign causes
      1. Tobacco abuse
      2. Peptic Ulcer Disease
      3. Inflammatory Bowel Disease
      4. Pancreatitis
      5. Hypothyroidism
      6. Cirrhosis
    2. Malignant causes
      1. Colon Cancer
      2. Breast Cancer
      3. Gastric Cancer
      4. Lung Cancer
      5. Pancreatic Cancer
      6. Bladder Cancer
      7. Cervical Cancer
      8. Melanoma
      9. Lymphoma
  6. Protocol for monitoring after Colorectal Cancer resection
    1. Repeat CEA level q2-3 months for 2 years
  7. References
    1. Bast (2001) J Clin Oncol 19:1865
    2. Fletcher (1996) Ann Intern Med 104:66
    3. Longo (2002) Surg Clin North Am 82(5):1091

Carcinoembryonic Antigen (C0007082)

Definition (MSH)A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
Definition (CSP)cancer specific antigen of colon carcinoma, also present in adenocarinomas of endodermal origin and in human embryonic gastrointestinal tissue.
Definition (NCI)Carcinoembryonic antigen. A substance that is sometimes found in an increased amount in the blood of people with certain cancers.
Definition (NCI)A cancer-specific antigen associated with both tumors and the developing fetus. The main use of this antigen is as a tumor marker, especially with respect to intestinal cancers. Production of the antigen ceases shortly before birth, but may reappear in people who develop certain types of cancer.
Definition (NCI)An antigen that is secreted onto the luminal surface of gastrointestinal epithelia and is found in pancreaticobiliary secretions. The antigen has been implicated as a facilitator of hepatic metastasis and is a cancer specific antigen of colon carcinoma. It is present in adenocarcinomas of endodermal origin and is localized in human embryonic gastrointestinal tissue.
ConceptsAmino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
EnglishANTIGENS CD 066E, carcinoembryonal antigen, Carcinoembryonic Ag, Carcinoembryonic Antigen, Carcinoembryonic Antigen CGM2, Carcinoembryonic antigens, CD 066 E ANTIGEN, CD66E, CD66E Ag, CD66e Antigen, CD66e Antigens, CEA, CEACAM5, Lymphocyte antigen CD66E, Meconium Antigen 100
Spanishantígeno carcinoembrionario, antígeno linfocitario CD66E, antigeno carcinoembrionario, antigeno linfocitario CD66E
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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