II. Indications: Higher risk of serious Allergic Reaction

  1. Antitoxin use (risk of Serum Sickness)
  2. Patients with history of multiple drug sensitivities

III. Preparation

  1. Discuss risks and benefits with patient
  2. Be prepared to treat Anaphylaxis

IV. Protocol: Administer prior to suspected medication

  1. Diphenhydramine (Benadryl) 1 mg/kg up to 50 mg IV
  2. Cimetidine (Tagamet) 6 mg/kg IV up to 300 mg IV

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