II. Indications

  1. Dermatophyte Infection
  2. Cutaneous Candidiasis
  3. Tinea Versicolor

III. Mechanism: Broad spectrum Antifungal activity

  1. Antifungal for dermatophytes and yeast
  2. Some Gram Positive antibacterial activity

IV. Medications: Twice daily dosing

  1. Clotrimazole 1% (Lotrimin, Mycelex, OTC)
  2. Miconazole nitrate 2% (Monistat-Derm, Micatin, OTC)
  3. Econazole nitrate 1% (Spectazole)

V. Medications: Once daily dosing (long durability agents)

  1. Ketoconazole 2% (Nizoral)
  2. Oxiconazole nitrate 1% (Oxistat)
  3. Sulconazole (Exelderm)

VI. Safety

  1. Topical azoles are considered safe in pregnancy
    1. Clotrimazole 1% for dermatophyte infections
    2. Miconazole 2% for candida infections

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Cost: Medications

clotrimazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CLOTRIMAZOLE 1% SOLUTION Generic OTC $2.66 per ml
CLOTRIMAZOLE 1% TOPICAL CREAM Generic OTC $0.05 per gram
CLOTRIMAZOLE 1% VAGINAL CREAM Generic OTC $0.08 per gram
CLOTRIMAZOLE 10 MG TROCHE Generic $0.38 each
CLOTRIMAZOLE-3 2% CREAM Generic OTC $0.31 per gram
CLOTRIMAZOLE-BETAMETHASONE CRM Generic $0.23 per gram
CLOTRIMAZOLE-BETAMETHASONE LOT Generic $2.65 per ml
econazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ECONAZOLE NITRATE 1% CREAM Generic $0.39 per gram
miconazole (on 4/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
MICONAZOLE 2% TOPICAL CREAM Generic OTC $0.11 per gram
MICONAZOLE 2% VAGINAL CREAM Generic OTC $0.14 per gram
MICONAZOLE 3 200 MG VAG SUPP Generic $12.11 each
MICONAZOLE 3 COMBO PACK Generic OTC $8.75 each
MICONAZOLE 7 100 MG VAG SUPP Generic OTC $1.17 each
MICONAZOLE 7 CREAM Generic OTC $0.14 per gram
MICONAZOLE-7 CREAM Generic OTC $0.14 per gram