II. Indications

  1. Refractory cutaneous dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Cruris)
    1. Shorter course (2 instead of 4 weeks) than Clotrimazole
    2. More convenient (once daily) than other Topical Antifungals

III. Mechanism

  1. Naphthalenemethylamine derivative
  2. Benzylamine similar to allylamines (e.g. Terbinafine, Naftifine)

IV. Dosing

  1. Apply once daily for 14 days to a 2 cm area surrounding Skin Infection
  2. Note: Unlike other Topical Antifungals, once daily application is sufficient

V. Efficacy

  1. High tinea cure rates with a 2 week course
  2. At 4-8 weeks, no significant difference in cure as compared with Clotrimazole

VI. Safety

  1. Pregnancy Category B
  2. Unknown safety in Lactation

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