II. Dosing

  1. Standard Dose: 5-20 mg up to once daily, 1 hour prior to intercourse
  2. Adjusted maximum dosing
    1. Hepatic insufficiency: 10 mg
    2. Age over 65 years: 5 mg

III. Pharmacokinetics

  1. Onset 30-60 minutes
  2. Duration: 4-5 hours

IV. Contraindications

  1. See Phosphodiesterase Inhibitors (PDE5)
  2. Men using nitrates (causes profound Hypotension)
  3. Men using alpha blockers (e.g. Hytrin for BPH)

V. Mechanism

VI. Drug Interactions

  1. See Phosphodiesterase Inhibitors (PDE5)
  2. Profound Vasodilitation and Hypotension with Nitroglycerin and alpha blockers such as Prazosin (Avoid)
  3. Cytochrome P3A4 related interactions (Cimetidine, systemic Antifungals, Protease Inhibitors and Macrolides

VII. Adverse Effects: Viagra (but most apply to the PDE5 Class as a whole)

  1. See Phosphodiesterase Inhibitors (PDE5)
  2. Hypotensive effect for men on Nitrates (Avoid)
  3. Vision effects (color vision, Vision Loss)
  4. Sensorineural Hearing Loss
  5. Mild Headache

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Cost: Medications

levitra (on 7/1/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
LEVITRA 10 MG TABLET $43.24 each
LEVITRA 20 MG TABLET $43.48 each
LEVITRA 5 MG TABLET $44.18 each

Ontology: vardenafil (C0971579)

Definition (NCI) A benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, prolonging penile erection.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C426063
SnomedCT 407979001, 404858007
LNC LP100060-5, MTHU035877
English vardenafil [Chemical/Ingredient], 1-(((3-(3,4-dihydro-5-methyl)-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine, vardenafil, VARDENAFIL, Vardenafil (product), Vardenafil (substance), Vardenafil
Spanish vardenafil (producto), vardenafil (sustancia), vardenafil

Ontology: Levitra (C1174890)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C426063
English Levitra, levitra, Bayer brand of vardenafil hydrochloride