II. Mechanism

  1. Free PSA increases more in Benign Prostatic Hypertrophy
  2. PSA associated with cancer is more protein bound

III. Indication

  1. Detection of Prostate Cancer when PSA 2.5 to 10 ng/ml

IV. Efficacy

  1. Improved Specificity when combined with PSA

V. Interpretation

  1. Free PSA >27% with lower likelihood of Prostate Cancer
  2. Values suggestive of Prostate Cancer
    1. Total PSA 3.0 to 4.0 with Free PSA <19%
    2. Total PSA 4.0 to 10.0 with Free PSA <17 to 24%

Images: Related links to external sites (from Bing)

Related Studies (from Trip Database) Open in New Window

Ontology: Prostate-Specific Antigen (C0138741)

Definition (NCI_NCI-GLOSS) A protein made by the prostate gland and found in the blood. Prostate-specific antigen blood levels may be higher than normal in men who have prostate cancer, benign prostatic hyperplasia (BPH), or infection or inflammation of the prostate gland.
Definition (NCI) Prostate-specific antigen (261 aa, ~29 kDa) is encoded by the human KLK3 gene. This protein plays a role in both proteolysis and seminal fluid liquefaction.
Definition (MSH) A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Definition (CSP) a tissue kallikrein related sequence enzyme used as a biomarker for prostate cancer or benign prostate hyperplasia.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126) , Immunologic Factor (T129)
MSH D017430
SnomedCT 102687007, 130634002, 143526001, 166158002
CPT 1011648
LNC LP18193-0, MTHU001466
English Prostate-Specific Antigen, Prostate Specific Antigen, Semenogelase, Seminin, gamma Seminoprotein, gamma-Seminoprotein, PSA-Prostate specific antigen, HK 003 KALLIKREIN, KALLIKREIN HK 003, P-30 antigen, prostate specific antigen, gamma seminoprotein, Kallikrein hK3, Kallikrein, hK3, hK3 Kallikrein, Prostate-Specific Antigen [Chemical/Ingredient], prostate specific antigen (PSA), prostate specific ag, psa antigen, Kallikrein-3, EC 3.4.21.77, Semenogelase (substance), Prostate specific antigen (procedure), Prostate specific Ag, Prostate specific Antigen, Prostate specific antigen (PSA), Prostate-specific antigen, prostate-specific antigen, PSA, Prostate specific antigen, PSA - Prostate specific antigen, Prostate specific antigen (substance), Antigen, Prostate-Specific, Gamma-Seminoprotein, KLK3, P-30 Antigen, Prostate Specific Antigen Preproprotein
Swedish Prostataspecifikt antigen
Czech prostatický specifický antigen, specifický antigen nádorů prostaty, PSA
Spanish APE - antígeno prostático específico, seminina, semenogelasa, antígeno P - 30, semenogelasa (sustancia), Antígeno Específico de la Próstata, Antígeno Próstata-Específico, antígeno prostático específico (sustancia), antígeno prostático específico, Antígeno Prostático Específico, Calicreína hK3, gamma Seminoproteína
Finnish Prostataspesifinen antigeeni
Russian PROSTATY SPETSIFICHESKII ANTIGEN, KALLIKREIN HK3, PREDSTATEL'NOI ZHELEZY SPETSIFICHESKII ANTIGEN, ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ СПЕЦИФИЧЕСКИЙ АНТИГЕН, ПРОСТАТЫ СПЕЦИФИЧЕСКИЙ АНТИГЕН, КАЛЛИКРЕИН HK3
French Antigène spécifique de la prostate, Kallikréine hK3, Semenogelase, Antigène PSA, gamma-Séminoprotéine, Kallikréine-3, Séminine, Kallikréine-3 humaine
German HK 003 KALLIKREIN, KALLIKREIN HK 003, Antigen, prostataspezifisches, Kallikrein,hK3-, Prostataspezifisches Antigen, hK3-Kallikrein, Gamma-Seminoprotein, PSA
Polish Antygen swoisty dla prostaty, PSA, Antygen sterczowy specyficzny, Antygen specyficzny gruczołu krokowego, Specyficzny antygen prostaty, Swoisty antygen sterczowy
Croatian PSA, PROSTATA SPECIFIČNI ANTIGEN
Japanese 前立腺特異抗原, セメノゲラーゼ, ガンマ-セミノプロテイン, ガンマセミノプロテイン, 前立腺特異性抗原, γ-セミノプロテイン, 抗原-前立腺特異, 抗原-前立腺特異性
Norwegian PSA-test
Portuguese PSA, Antígeno Específico da Próstata, Antígeno Prostático Específico, Calicreína hK3, gama-Seminoproteína, hK3 Calicreína
Italian Antigene specifico della prostata