II. Background

  1. American Joint Committee on Cancer TNM Staging of Bladder Cancer

III. Staging: Grouping

  1. Stage 0a: Ta N0 M0
  2. Stage 0is: Tis N0 M0
  3. Stage I: T1 N0 M0
  4. Stage II: T2a-2b N0 M0
  5. Stage III: T3a-4a N0 M0
  6. Stage IV: T4b N0-3 M0-1 (or any T if node positive or metastases present)

IV. Staging: Primary Tumor Staging: T

  1. T0: No tumor present
  2. Tis: Carcinoma in situ
  3. Ta: Papillary tumor with only Bladder mucosa involved
  4. T1: Extension into Bladder lamina propria
  5. T2: Invasion into Bladder superficial muscle
  6. T3a: Invasion into Bladder deep muscle
  7. T3b: Invasion into fat surrounding Bladder
  8. T4a: Regional spread into Prostate, vagina or Uterus
  9. T4b: Tumor fixed to pelvic or abdominal wall
  10. TX: Unable to assess primary tumor

V. Staging: Lymph Node Staging: N

  1. N0: No lymph node involvement found
  2. N1: Single unilateral regional node involvement
  3. N2: Contralateral or bilateral lymph nodes involved
  4. N3: Fixed mass of regional lymph nodes
  5. N4: Juxtaregional lymph node involvement
  6. NX: Unable to assess lymph node involvement

VI. Staging: Distant Metastatic Spread Staging: M

  1. MO: No distant metastasis identified
  2. M1: Distant metastasis found
  3. MX: Unable to assess metastases

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