II. Risk Factors

  1. Bladder neck or Urethral injury
  2. Sphincter weakness from neurologic injury
  3. Medications that relax the Urethral sphincter
    1. Example: Alpha-adrenergic antagonists
    2. See Urinary Incontinence due to Medications
  4. Decreased Pelvic Floor Competence
    1. Normal aging
    2. Surgery
    3. Multiparity
    4. Postpartum (20-30% at 3 months postpartum)
      1. Glazener (2001) BMJ 323:593-6 [PubMed]

III. Pathophysiology

  1. Bladder outlet less than intravesicular pressure
  2. Weakness of pelvic floor or Bladder neck support
    1. Bladder neck descends below pelvic floor on exertion
    2. Bladder neck opens
    3. Only sphincter (weak) can hold back urine
  3. Triggers (e.g. cough, sneeze) transiently increase intra-abdominal pressure
    1. Results in involuntary small-volume leakage of urine

IV. Symptoms

  1. Small amounts of urine lost
    1. Contrast with large volumes in Urge Incontinence
  2. Urine loss stops immediately after activity stops
  3. Immediately after increased intrabdominal pressure
    1. Cough
    2. Sneeze
    3. Laugh
    4. Heaving or straining

V. Signs

  1. Leakage after Valsalva or cough with full Bladder
    1. See Bladder Stress Test
  2. Weakness or protrusion
    1. Anterior vaginal wall
    2. Urethra
    3. Bladder

VI. Diagnostics

  1. Bladder volumes (evaluate for other Incontinence causes)
    1. Post-void residual under 50 cc
    2. Bladder Capacity under 400 cc

VII. Management: General Measures (most effective)

  1. Pelvic Floor Exercises (maintay of Stress Incontinence management)
    1. Kegal Exercises
    2. Vaginal weight training (Vaginal cones)
  2. Physical Therapy
    1. Biofeedback (visualize pelvic floor contractions)
      1. Highly effective in elimination of Incontinence
      2. Dumoulin (2004) Obstet Gynecol 104:504-10 [PubMed]
    2. Functional electrical stimulation
      1. Transvaginal or Transrectal electrode applied via probe
        1. Patient performs at home for 15 minutes twice daily for 2 weeks
        2. Indicated for Stress Incontinence refractory to standard Pelvic Floor Exercises
        3. Especially useful in women who are unable to voluntarily contract pelvic floor muscles
      2. Extracorporeal magnetic innervation (ExMI)
        1. FDA approved for mild Stress Incontinence in patients who have not undergone Incontinence surgery
        2. Patients sits fully clothed on chair that generates low powered electric field
        3. Performed for 20 minutes, 2-3 times weekly for 6-8 weeks
        4. Gilling (2009) BJU int 103(10): 1386-90 [PubMed]
  3. Vaginal devices
    1. General
      1. Indicated in pregnancy, non-surgical patients, or Stress Incontinence patients with refractory course
      2. Most devices (except Urethral plug) work by compressing Bladder neck and Urethra
    2. Pessaries
      1. Low cost, safe and immediately effective in Stress Incontinence
      2. Consider in older patients
      3. Risk of vaginal infection or local Trauma
      4. Contraindicated in active pelvic infection, vaginal ulceration, or allergy to materials in Pessary
    3. Diaphragms
    4. Incontinence tampon
      1. Only available in Europe as of 2013
    5. Bladder neck support prosthesis (e.g. Milex)
      1. Used temporarily (e.g. during Exercise)
    6. Urethral Occlusion insert
      1. Urethral inserts (5 cm long) used for brief planned activities (e.g. during Exercise)
      2. Risk of Urinary Tract Infection (>30% over 2 years) and migration into Bladder (1%)
  4. Situational
    1. Weight loss (in Obesity)
    2. Tobacco Cessation
    3. Planned fluid intake and timed voiding
    4. Constipation Management
    5. Eliminate provocative medications
    6. Collection or absorption products

VIII. Management: Medications

  1. General
    1. Medications are not effective in Stress Incontinence
      1. Duloxetine is a possible exception
    2. Avoid Anticholinergics (e.g. Oxybutynin)
      1. Not effective in Stress Incontinence
  2. Duloxetine (Yentreve, Cymbalta)
    1. SNRI that stimulates Urethral sphincter contraction
    2. Not FDA approved - but appears effective in some cases
  3. Topical Estrogen
    1. Indicated for Postmenopausal Atrophic Vaginitis
    2. Greater efficacy seen in Urge Incontinence
    3. Estrogen not effective in Stress Incontinence
      1. Fantl (1996) Obstet Gynecol 88:745-9 [PubMed]
  4. Alpha adrenergic agonists
    1. No strong evidence supporting use
    2. Preparations
      1. Phenylpropanolamine
      2. Pseudoephedrine
    3. Mechanism
      1. Increases Bladder outlet smooth muscle tone
  5. Tricyclic Antidepressants (Imiprimine)
    1. Indications
      1. Mixed Urge Incontinence and Stress Incontinence
      2. Not indicated in Stress Incontinence alone
    2. Mechanism
      1. Anticholinergic
      2. Direct relaxant of detrussor
      3. Alpha-adrenergic-Bladder outlet tone increased

IX. Management: Minimally-Invasive Procedures

  1. Radiofrequency Denaturation
    1. Single-time, office-based procedure in which radiofrequency device inserted into Urethra
    2. Delivered energy denatures collagen and reduces compliance in Bladder neck and proximal Urethra
    3. Improvement in up to 50% of patients for as long as 3 years after single procedure
    4. Adverse effects: Urinary Tract Infections, Dysuria
    5. Lukban (2012) Obstet Gynecol Int 2012:384234 [PubMed]
  2. Collagen injection into periurethral area (e.g. Durasphere Transurethral injection)
    1. Effective, but Incontinence may recur with time
    2. Indicated for intrinsic sphincter deficiency
    3. Improvement in up to 40% following procedure (may require repeat procedures)
    4. Adverse effects: Urinary Tract Infections, Dysuria, Urinary Retention

X. Management: Surgical

  1. Slings (pubovaginal or midurethral)
    1. Tension-free vaginal tape (TVT)
      1. Urethral sling placed under Local Anesthesia
      2. More effective than colposuspension
      3. Valpas (2004) Obstet Gynecol 104:42-9 [PubMed]
    2. Other slings
      1. Retropubic sling
      2. Sing incision sling (mini-sling)
      3. Transobturator sling
  2. Urethropexy (or colposuspension)
    1. Keyhole, Needle or laparoscopic colposuspension (urethropexy)
    2. Retropubic colposuspension or urethropexy (Burch Suspension, Marshall-Krantz Procedure)
      1. Elevate UVJ above pelvic floor
      2. Effective, but Incontinence may recur with time
      3. Indicated in Uterine Prolapse

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Ontology: Urinary Stress Incontinence (C0042025)

Definition (CCC) Loss of urine occurring with increased abdominal pressure
Definition (NAN) Loss of less than 50 ml of urine occurring with increased abdominal pressure
Definition (MSH) Involuntary discharge of URINE as a result of physical activities that increase abdominal pressure on the URINARY BLADDER without detrusor contraction or overdistended bladder. The subtypes are classified by the degree of leakage, descent and opening of the bladder neck and URETHRA without bladder contraction, and sphincter deficiency.
Concepts Disease or Syndrome (T047)
MSH D014550
ICD10 N39.3
SnomedCT 22220005, 14624007, 266668007, 139400003, 162124008, 197943008, 156028007
LNC MTHU013445
English Incontinence, Urinary Stress, Urinary Incontinence, Stress, Stress Incontinence, Urinary, Stress incontinence, GSI - Genuine stress incontin, stress incontinence (diagnosis), stress incontinence, Stress Incontinence, Urinary Stress Incontinence, Urinary Incontinence, Stress [Disease/Finding], rndx stress urinary incontinence (diagnosis), rndx stress urinary incontinence, genuine stress incontinence, incontinence stress urinary, incontinence stressed urinary, Incontinence;urine;stress, incontinence stress, incontinence urinary stress, urinary stress incontinence, Stress incontinence - symptom, Stress urinary incontinence (disorder), Stress incontinence (& symptom), Incontinence - stress, Genuine stress incontinence (disorder), Stress incontinence (& symptom) (finding), Stress Urinary Incontinence, Stress bladder incontinence, Urinary stress incontinence, Genuine stress incontinence, Incontinence when straining, GSI - Genuine stress incontinence, SI - Stress incontinence, Genuine stress incontinence (finding), Stress urinary incontinence, STRESS URINARY INCONTINENCE, incontinence; stress, incontinence; urinary, stress, stress; incontinence, urine; incontinence, stress, stress urinary incontinence
Dutch stress incontinentie, stress-urine-incontinentie, incontinentie; stress, incontinentie; urine, stress, stress; incontinentie, urine; incontinentie, stress, Stress-incontinentie, Incontinentie, stress-, Stressincontinentie
French Incontinence urinaire provoquée par le stress, Incontinence d'effort, IUE (Incontinence Urinaire d'Effort ), Incontinence urinaire d'effort, Incontinence d'urine à l'effort
German Stress-Urininkontinenz, Streßinkontinenz, Stressinkontinenz, Streßharninkontinenz, Inkontinenz, Streß-, Harninkontinenz, Streß-, Stressharninkontinenz
Italian Incontinenza da sforzo, Incontinenza urinaria da stress, Incontinenza urinaria da sforzo
Portuguese Incontinência urinária de stress, Incontinência de stress, Incontinência Urinária de Esforço, Incontinência Urinária por Estresse
Spanish Incontinencia urinaria por estrés, Incontinencia por estrés, incontinencia urinaria de esfuerzo, incontinencia vesical de esfuerzo, incontinencia urinaria de esfuerzo (concepto no activo), incontinencia de esfuerzo (hallazgo), incontinencia de esfuerzo, Incontinencia Urinaria de Esfuerzo
Swedish Ansträngningsinkontinens
Japanese フクアツセイニョウシッキン, 尿失禁-緊張性, 緊張性失禁, 緊張性尿失禁, 腹圧性尿失禁, ストレス尿失禁, 失禁-緊張性, 尿失禁-ストレス, 尿失禁-腹圧性
Finnish Rasitusinkontinenssi
Russian NEDERZHANIE MOCHI STRESSOVOE, NEDERZHANIE MOCHI NEVROGENNOE, НЕДЕРЖАНИЕ МОЧИ НЕВРОГЕННОЕ, НЕДЕРЖАНИЕ МОЧИ СТРЕССОВОЕ
Czech Stresová inkontinence, Stresová močová inkontinence, stresová inkontinence moči, moč - inkontinence stresová
Korean 복압 요실금
Croatian URINARNA STRES INKONTINENCIJA
Polish Wysiłkowe nietrzymanie moczu, Nietrzymanie moczu wysiłkowe
Hungarian Stress vizelet-incontinentia, stress-incontinentia
Norwegian Stressurininkontinens, Urinkontinens, stress, Stressinkontinens