II. Mechanism

  1. Barbiturate

III. Dose

  1. Dose: 2.5 mg/kg IV (may repeat additional 1.25 mg/kg as needed twice)
  2. Observe for Hypotension

IV. Indications: Brief Procedural Sedation

  1. Rare use in U.S. now
  2. Ideal for CT Head (brief action, Seizure Prophylaxis)
  3. May be accompanied to CT with RN (low risk of respiratory depression, or other serious adverse effects)

V. Adverse Effects

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Ontology: Pentobarbital (C0030883)

Definition (MSH) A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Definition (CSP) short to intermediate acting barbiturate used as a sedative and hypnotic; the sodium salt is also used as an anticonvulsant, as a preanesthetic and as an adjunct to anesthesia.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D010424
SnomedCT 360214003, 33231001, 372703009
LNC LP16241-9, MTHU003433
English Mebubarbital, Pentobarbital, Pentobarbitone, 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-, Pentobarbital [Chemical/Ingredient], pentobarbitone, PENTobarbital, pentobarbital (discontinued), pentobarbital (medication), Pentobarbitone - chemical (substance), Pentobarbitone - chemical, pentobarbital, Pentobarbital (product), Pentobarbital (substance), PENTOBARBITAL
Swedish Pentobarbital
Czech pentobarbital
Finnish Pentobarbitaali
Russian NEMBUTAL, ETAMINAL, PENTOBARBITAL, MEBUMAL, NEBUMAL, MEBUBARBITAL, МЕБУБАРБИТАЛ, НЕБУМАЛ, НЕМБУТАЛ, ПЕНТОБАРБИТАЛ, ЭТАМИНАЛ, МЕБУМАЛ
Japanese ペントバルビタール, メブマール, メブバルビタール
Italian Pentobarbitone, Pentobarbital
Spanish pentobarbitona - compuesto químico, pentobarbital - compuesto químico (sustancia), pentobarbital - compuesto químico, pentobarbital (producto), pentobarbital (sustancia), pentobarbital, pentobarbitona - compuesto químico (sustancia), pentobarbitona, Mebubarbital, Pentobarbital
Polish Nembutal, Pentobarbital
French Pentobarbital
German Mebubarbital, Pentobarbital
Portuguese Mebubarbital, Pentobarbital