II. Indications

III. Precautions

  1. Results altered by Hyperkalemia Management
  2. Obtain lab sample prior to intervention if possible
    1. Do not delay treatment in emergent Hyperkalemia

V. Calculation: Transtubular Potassium Gradient (TTPG)

  1. TTPG = (Urine K+ x Serum Osm)/(Serum K+ x Urine Osm)
  2. Where K+ is Potassium and Osm is Osmolality

VI. Interpretation: Fractional Excretion of Potassium

  1. TTPG <6-8%: Renal cause of Hyperkalemia
    1. Hypoaldeosteronism suggested by very low TTPG
  2. TTPG >6-8: Extrarenal cause of Hyperkalemia
    1. May also be increased in Chronic Renal Failure

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