II. Normal

  1. Adults
    1. Men: 0.8 to 1.3 mg/dl
    2. Women: 0.6 to 1.0 mg/dl
  2. Children (under age 20 years)
    1. Boys: 0.35 + (age in years)/40
    2. Girls: 0.35 + (age in years)/55

III. Protocol: New

  1. Standardized Creatinine (S-Creatinine)
    1. New, more accurate technique for measuring Serum Creatinine
    2. Not as affected by interfering substances
    3. Expect a drop in Serum Creatinine of 20% when switching to S-Creatinine measurement

IV. Pathophysiology

  1. Increases by 1.0-1.5 mg/dl/day if no Renal Function
  2. Often unchanged until 25-50% of Renal Function lost
  3. Doubled Serum Creatinine implies 50% Renal Function

V. Increased

  1. Renal Insufficiency
  2. Decreased renal perfusion
  3. Urinary Tract Infections
  4. Skeletal muscle Trauma or Rhabdomyolysis
  5. Ketonemia
  6. Diabetic Ketoacidosis
  7. Creatine Supplementation >15-20 grams per day
    1. May increase Serum Creatinine over 2.0
  8. Medications (Inhibit tubular secretion of Creatinine)
    1. Aminoglycosides
    2. Cephalosporins
      1. Cefoxitin
      2. Cephalothin
    3. Hydantoin
    4. Diuretics
    5. Methyldopa
    6. Cimetidine
    7. Trimethoprim

VI. Decreased

  1. Decreased muscle mass
  2. Pregnancy

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Ontology: Creatinine (C0010294)

Definition (NCI) The breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.
Definition (NCI_NCI-GLOSS) A compound that is excreted from the body in urine. Creatinine levels are measured to monitor kidney function.
Definition (CSP) nitrogen compound in muscle, blood and urine that is the end product of creatine metabolism.
Concepts Biologically Active Substance (T123) , Organic Chemical (T109)
MSH D003404
SnomedCT 15373003
LNC LP14355-9, LP32035-5, MTHU002337
English Creatinine, 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-, Creatinine [Chemical/Ingredient], creatinine, creatinines, CREATININE, Creatinine (substance)
Swedish Kreatinin
Czech kreatinin
Finnish Kreatiniini
Russian KREATININ, КРЕАТИНИН
Japanese クレアチニン, メチルグアニジノ酢酸, メチルグリコシアミジン
Croatian KREATININ
Polish Kreatynina
Spanish creatinina (sustancia), creatinina, Creatinina
French Créatinine
German Creatinin, Kreatinin
Italian Creatinina
Portuguese Creatinina