III. Indication

  1. Insomnia
  2. Consider for early awakening in middle of night

IV. Pharmacokinetics

  1. Half-Life: 1 hour
  2. Peak Onset: 30 minutes
  3. Duration
    1. Typically 4 hours, but may be as long as 6-8 hour
  4. Metabolized by CYP450 3A4

V. Dosing

  1. Start: 5-10 mg orally at bedtime
  2. Elderly: 5 mg orally at bedtime
  3. Maximum: 20 mg orally at bedtime

VI. Adverse Effects

  1. See Nonbenzodiazepine Hypnotic Agent for common effects
  2. Altered color perception

VII. Advantages

  1. See Nonbenzodiazepine Hypnotic Agent
  2. Effective in middle of night awakening
    1. Can take mid-way through sleep period

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Cost: Medications

zaleplon (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
ZALEPLON 10 MG CAPSULE Generic $0.29 each
ZALEPLON 5 MG CAPSULE Generic $0.23 each
sonata (on 6/1/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
SONATA 10 MG CAPSULE Generic $0.29 each

Ontology: zaleplon (C0251504)

Definition (NCI) A nonbenzodiazepine from the pyrazolopyrimidine class with hypnotic, sedative, anxiolytic, and muscle relaxant properties. Zaleplon interacts with the gamma-aminobutyric acid (GABA) -A receptor, thereby affecting the chloride channel ionophore complex and potentiating the inhibitory effects of GABA. In addition, zaleplon binds selectively to the brain omega-1 receptor situated on the alpha subunit of the GABA-A/chloride ion channel receptor complex and potentiates t-butyl-bicyclophosphorothionate (TBPS) binding.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C085665
SnomedCT 321187004, 116104009, 387012004
LNC LP30650-3, MTHU015092
English Acetamide, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethyl-, N-(3-(3-cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethylacetamide, zaleplon, zaleplon (medication), ZALEPLON, zaleplon [Chemical/Ingredient], Zaleplon (product), Zaleplon (substance), Zaleplon
Spanish zaleplón (producto), zaleplón (sustancia), zaleplón

Ontology: Sonata (C0876170)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C085665
English Sonata, sonata, Lundbeck brand of zaleplon, Wyeth brand of zaleplon, Zelepion, AHP brand of zaleplon