II. Class

  1. Long acting Benzodiazepine

III. Indications

IV. Dose

  1. Insomnia
    1. 7.5-30 mg PO qhs
  2. Anxiety
    1. Maximum Daily Dose: 15 mg

V. Pharmacokinetics

  1. Half-Life: 39 hours

VI. Background

  1. Weekly Cost: $5.08

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Ontology: quazepam (C0072828)

Definition (NCI) A synthetic benzodiazepine derivative with anxiolytic, sedative and hypnotic properties. Quazepam and its major metabolite 2-oxoquazepam potentiate gamma-aminobutyric acid (GABA) activity by binding to the benzodiazepine-1 recognition site (BZ-1) within the GABA-A receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of GABA-activated chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreased neuronal excitability.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C025130
SnomedCT 108391004, 371372004
LNC LP17870-4, MTHU024725
English 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione, quazepam, 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-, quazepam (medication), quazepam [Chemical/Ingredient], QUAZEPAM, Quazepam (substance), Quazepam product (product), Quazepam product, Quazepam
Spanish quazepam, producto (producto), quazepam (producto), quazepam, quazepam, producto, quazepam (sustancia), cuacepam (sustancia), cuazepam, cuacepam

Ontology: Doral (C0720023)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C025130
English Doral, doral, Wallace brand of quazepam