II. Precautions

  1. Pregnancy Category: D

III. Preparations: Nicotine Lozenges

  1. Available over the counter in the United States
  2. Caution: Lozenges contain 25% more nicotine than the Nicotine Gum
  3. Heavy smokers: 4 mg
    1. Use of 25 Cigarettes per day
    2. First Cigarette within 30 minutes of awakening
  4. Moderate smokers: 2 mg
    1. Less than 25 Cigarettes per day

IV. Dosing

  1. Maximum: 20 lozenges daily
  2. Avoid food or drink 15 minutes before gum
    1. Avoid acidic foods and beverages 30 minutes prior to use
  3. Taper schedule
    1. Week 1-6: One lozenge every 1-2 hours
    2. Week 7-9: One lozenge every 2-4 hours
    3. Weeks 10-12: One lozenge every 4-8 hours

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Ontology: Nicotine Lozenge (C1253423)

Definition (NCI_NCI-GLOSS) A hard candy-like tablet that contains a small dose of nicotine. The nicotine is absorbed through the lining of the mouth and goes into the blood. This helps stop nicotine cravings, and relieves symptoms that occur when a person is trying to quit smoking. A prescription is not needed for nicotine lozenges.
Definition (NCI) A lozenge preparation containing the alkaloid nicotine with nicotine replacement activity. Upon administration of the lozenge, nicotine is released and, although nicotine binds to nicotinic cholinergic receptors at the autonomic ganglia, adrenal medulla and at neuromuscular junctions as well, the binding of nicotine to the receptors in the central nervous system (CNS) appears to be responsible for the addictive nature of nicotine. Binding to CNS nicotinic acetylcholine receptors causes the release of the neurotransmitter dopamine which appears to be responsible for the addiction of nicotine. Administration of nicotine may prevent nicotine craving and may help with the withdrawal symptoms associated with smoking cessation.
Concepts Clinical Drug (T200)
MSH D061485
SnomedCT 391879005
English nicotine lozenge, lozenges nicotine, nicotine lozenges, Lozenge, Nicotine, Nicotine Lozenge, Lozenges, Nicotine, Nicotine Lozenges, Nicotine Oral Lozenge, Nicotine lozenges (product), Nicotine lozenges
French Tablette à la nicotine, Pastille de nicotine, Tablette de nicotine, Pastille à la nicotine
German Nikotin Lozenge
Spanish nicotina, comprimido de disolución oral (producto), nicotina, comprimido de disolución oral