II. Physiology

  1. Neurotransmitter
    1. Motor control
    2. Pain perception
    3. Sympathetic Nervous System outflow
  2. Synthesis from essential amino acid L-tryptophan
  3. Serotonin Receptors
    1. Serotonin-1 Receptor (5-HT-1) Activity
      1. Anti-depressant effect
    2. Serotonin-2 Receptor (5-HT-2) Activity
      1. Inhibits 5-HT-1 Receptor
      2. Causes Sexual Dysfunction
      3. Causes Insomnia
      4. Causes anxiety
    3. Serotonin-3 Receptor (5-HT-3) Activity
      1. Causes Gastrointestinal symptoms
      2. Causes Headache

III. Medications: Increase Serotonin levels

  1. Increased Serotonin synthesis: L-Tryptophan
  2. Decrease Serotonin metabolism: MAO inhibitors
  3. Increase Serotonin release: Amphetamines, Cocaine
  4. Inhibit Serotonin uptake
    1. Tricyclic Antidepressants: Amitriptyline
    2. Selective Serotonin Reuptake Inhibitor (SSRI): Prozac
    3. Other: Meperidine, Dextromethorphan
  5. Direct Serotonin Receptor Agonists: Buspar, Imitrex
  6. Dopamine Agonists: Amantadine, Wellbutrin, Levodopa
  7. Other Non-specific Serotonin increase: Lithium

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Ontology: Serotonin (C0036751)

Definition (NCI_NCI-GLOSS) A hormone found in the brain, platelets, digestive tract, and pineal gland. It acts both as a neurotransmitter (a substance that nerves use to send messages to one another) and a vasoconstrictor (a substance that causes blood vessels to narrow). A lack of 5-hydroxytryptamine in the brain is thought to be a cause of depression.
Definition (MSH) A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Definition (CSP) biochemical messenger and regulator, synthesized from tryptophan; in humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets.
Concepts Neuroreactive Substance or Biogenic Amine (T124) , Organic Chemical (T109)
MSH D012701
SnomedCT 33635003
LNC LP14693-3, MTHU005043
English 5 Hydroxytryptamine, 5-HT, 5-Hydroxytryptamine, Serotonin, 1H-Indol-5-ol, 3-(2-aminoethyl)-, 3-(2-Aminoethyl)-1H-indol-5-ol, HYDROXYTRYPTAMINE A 05, HT 05, 5 hydroxytryptamine, 5HT, Enteramine, Hippophaine, 5-hydroxytryptamine, Serotonin [Chemical/Ingredient], serotonins, serotonin, 5 hydroxy tryptamine, 5 ht, 5ht, 5-ht, SEROTONIN, 5-Hydroxy tryptamine, 5-HT - 5-Hydroxytryptamine, Serotonin (substance), Hydroxytryptamine (5-)
German Enteramin, HYDROXYTRYPTAMIN A 05, HT 05, 5-HT, 5-Hydroxytryptamin, Serotonin
Swedish Serotonin
Czech 5-hydroxytryptamin, 5-HT, serotonin, hydroxytryptamin
Finnish Serotoniini
Japanese セロトニン, 5-ヒドロキシトリプタミン
French Entéramine, 5-Hydroxytryptamine, 5-Hydroxy-tryptamine, Sérotonine
Polish Serotonina, Hydroksytryptamina, 5-HT, Układ serotoninergiczny
Spanish 5 - hidroxi triptamina, 5 - hidroxitriptamina, serotonina (sustancia), serotonina, 5-HT, Serotonina, 5-Hidroxitriptamina
Italian Serotonina
Portuguese 5-HT, 5-Hidroxitriptamina, Serotonina