II. Background

  1. Fat-soluble, Vitamin-like quinone
  2. Endogenous compound used in energy metabolism
  3. Highest concentrations in heart, brain, liver, Kidney
  4. Activity
    1. Central to electron transfer in ATP production
    2. Antioxidant scavenger
    3. Decreases calcium overload
    4. Protective against ischemia in CHF

III. Indications: Neurologic

IV. Indications: Cardiovascular (50-200 mg/day)

  1. Congestive Heart Failure (CHF) - unclear benefit
  2. Hypertension - insufficient evidence
  3. Coronary Artery Disease - experimental

V. Indications: Miscellaneous

  1. Diabetes Mellitus (100-200 mg/day) - unclear benefit

VI. Adverse effects

  1. Gastrointestinal upset
  2. Potential risk of Hypoglycemia, Hypotension

VII. Disadvantages

  1. Expensive: (1200 mg/day costs $300/month)

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Ontology: coenzyme Q10 (C0056077)

Definition (NCI_NCI-GLOSS) A nutrient that the body needs in small amounts to function and stay healthy. Coenzyme Q10 helps mitochondria (small structures in the cell) make energy. It is an antioxidant that helps prevent cell damage caused by free radicals (highly reactive chemicals). Coenzyme Q10 is fat-soluble (can dissolve in fats and oils) and is found in fatty fish, beef, soybeans, peanuts, and spinach. It is being studied in the prevention and treatment of some types of cancer and heart disease and in the relief of side effects caused by some cancer treatments.
Definition (NCI) A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme Q10 functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme Q10 may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. (NCI04)
Definition (PDQ) A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme-Q functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme-Q may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39187&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39187&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C916" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109) , Biologically Active Substance (T123)
MSH C024989
SnomedCT 412129003, 412130008
English 2,3-dimethoxy-5-methyl-6-decaprenylbenzoquinone, CoQ 10, CoQ10, ubiquinone 50, ubiquinone Q10, coenzyme Q10, coenzyme-Q10, coenzyme Q10 (medication), Bio-Quinone Q10, coenzyme Q10 [Chemical/Ingredient], coenzymes q10, q10 ubiquinone, coenzyme q10, coq10, coq 10, q10 coenzyme, UBIDECARENONE, ubidecarenone, Co Q-10, vitamin Q10, Q10, Co-Q10, Coenzyme Co Q10, Coq10, Coenzyme Q10, Coenzyme Q10 (product), Coenzyme Q10 (substance), Ubidecarenone, COENZYME Q10
Spanish coenzima Q10 (producto), coenzima Q10 (sustancia), coenzima Q10, ubidecarenona