II. Preparations: Supplements (OTC)

  1. Supplement sources
    1. Cod liver oil
    2. Standard fish body oil
    3. Omega-3 Fatty Acid concentrate
  2. Supplement Capsules (1 gram)
    1. Eicosapentaenoic Acid (EPA): 180 mg
    2. Docosahexaenoic Acid (DHA): 120 mg
  3. Liquid
    1. Variable concentrations per manufacturer
  4. Food sources for acquiring in diet
    1. See Omega-3 Fatty Acid

III. Preparations: Prescriptions

  1. Lovaza
    1. Contents (per 1 gram capsule)
      1. EPA 465 mg
      2. DHA 375 mg
    2. Efficacy (4 gram/day dose)
      1. Lowers Triglycerides 45%
      2. Risk of increased LDL Cholesterol
  2. Vascepa
    1. Contents (per 1 gram capsule)
      1. EPA 1000 mg
    2. Efficacy (4 gram/day dose)
      1. Lowers Triglycerides 27%
  3. References
    1. (2013) Presc Lett 20(1):1-2
    2. Ballantyne (2012) Am J Cardiol 110(7):984-92 [PubMed]

IV. Dosing

  1. Standard dosing: 1 gram capsule or equivalent liquid daily
    1. Coronary Artery Disease Prevention
    2. Does not appear effective (at 1 g dose) for CAD primary prevention in those without CAD
      1. Halim (2012) Ann Intern Med 157(4):JC2-3 [PubMed]
  2. Higher dose: 2-4 grams per day
    1. Hypertriglyceridemia
    2. Currently being researched as to benefits and risks
      1. Hypertension
      2. Rheumatoid Arthritis

V. Efficacy

VI. Adverse Effects

  1. Well tolerated in most patients
  2. Fish after-taste
  3. Gastrointestinal upset
  4. Prolonged Bleeding Time
  5. Increased LDL Cholesterol
  6. Mercury Poisoning risk (depending on source of extract)

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