II. Mechanism

  1. Seeds contain essential Fatty Acid
    1. Linoleic Acid
    2. Gamma-linolenic acid (GLA), a Omega 6 Fatty Acid
  2. Linoleic Acid is precursor to Prostaglandin E
    1. May replace deficiency in Premenstrual Syndrome

III. Contraindications

  1. Seizure disorder
  2. Concurrent Antipsychotic Medication

IV. Indications: Current use (preliminary studies suggest it is likely ineffective for most proposed uses)

V. Dosing

  1. Evening Primrose Oil 500 mg capsules, 6 per day

VI. Adverse Effects

  1. Well tolerated
  2. Nausea
  3. Diarrhea
  4. Stool softening
  5. Headache
  6. May predispose to Seizure disorder

VII. Efficacy

  1. Variable results in studies
  2. Small trials suggest unlikely benefit for most proposed indications
    1. Atopic Dermatitis
    2. Mastalgia
    3. Menopause
    4. Premenstrual Syndrome
  3. Insufficient evidence to support the use for other indications
    1. Diabetic Neuropathy
    2. Rheumatoid Arthritis

VIII. Drug Interactions: Possible interactions

  1. Phenothiazine Neuroleptics
  2. Anticonvulsants

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