II. Indications

  1. Second line drug for Migraine Prophylaxis
  2. Use only with Neurology Consultation (due to toxicity)

III. Mechanism

  1. Serotonin Antagonist (partial agonist activity)

IV. Dosing

  1. Sansert 4-8 mg PO qd
  2. Drug holiday for 4 weeks every 6 months

V. Adverse Effects

  1. Retroperitoneal fibrosis
  2. Weight gain
  3. Edema

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Ontology: Methysergide (C0025842)

Definition (MSH) An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008784
SnomedCT 363566005, 11796006, 387044000
English Dimethylergometrin, Methylmethylergonovine, Methysergide, Ergoline-8-carboxamide, 9,10-didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethyl-, (8beta(S))-, Methysergide [Chemical/Ingredient], Methysergide product, Methysergide product (substance), methysergide, Methysergide (product), Methysergide (substance), methylsergide, METHYSERGIDE
Swedish Metysergid
Czech methysergid
Finnish Metysergidi
Russian DIMETILERGOMETRIN, METIZERGID, METILMETILERGONOVIN, ДИМЕТИЛЭРГОМЕТРИН, МЕТИЗЕРГИД, МЕТИЛМЕТИЛЭРГОНОВИН
Japanese メチルメチルエルゴノビン, メチセルギド, デセリル, マレイン酸メチセルギド, メチセルギドマレイン酸塩, サンサート, ジメチルエルゴメトリン, マレイン酸水素メチセルギド
Portuguese Metilmetilergonovin, Metisergida, Dimetilergometrina
Croatian METIZERGID
Polish Sansert, Deseril, Metysergid
Spanish metisergida (producto), metisergida (sustancia), metisergida, Dimetilergometrina, Metilmetilergonovina, Metisergida
French Méthysergide
German Dimethylergometrin, Methylmethylergonovin, Methysergid
Italian Metisergide

Ontology: Sansert (C0036177)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D008784
English sansert, deseril, desril, Sansert, Deseril, Desril, Alliance Brand of Methysergide Maleate, Désernil Sandoz, Désernil-Sandoz, Novartis Brand of Methysergide Maleate