Pharm

Adalimumab

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Adalimumab, Humira

  • Indications
  1. Severe active Rheumatoid Arthritis refractory to DMARDs
  • Contraindications
  1. Chronic or acute infection
  2. Concurrent use of Interleukin-1 Receptor Antagonist
    1. Anakinra (Kineret)
  1. Human antitumor Necrosis Factor alpha
  2. Similar to Infliximab and Etanercept
  • Dosing
  1. Every other week: 40 mg SC
  • Adverse Effects
  1. Immunosuppression
    1. Use caution in any patient prone to infection
  2. Headache
  3. Rash
  4. Hypertension
  5. Hyperlipidemia
  6. Injection site inflammation
  7. Gastrointestinal upset
  • Cost
  1. Two 40 mg vials: $1200 (in 2003)
  • References
  1. (2003) Lexi-Comp Drug Database