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Ototoxic Drug

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Ototoxic Drug, Ototoxic Medication, Ototoxicity

  • Causes
  • Medications
  1. Analgesics
    1. Aspirin (>2.7 g/day) and other Salicylates
    2. NSAIDs
    3. Acetaminophen
    4. Sulfasalazine (Azulfidine)
  2. Antibiotics
    1. Aminoglycosides
      1. Starts with Tinnitus and rapidly progresses to Hearing Loss
      2. Ototoxicity symptoms are permanent if last >2-3 weeks after stopping the Aminoglycoside
    2. Streptomycin
    3. Vancomycin
    4. Erythromycin (dose >2 g/day) and other Macrolides
    5. Chloramphenicol
    6. Doxycycline or Minocycline (transient vestibular toxicity)
    7. Imipenem-Cilastin (Primaxin)
    8. Linezolid (Zyvox)
    9. Sulfonamide
    10. Fluoroquinolones
    11. Voriconazole
    12. Amphoteracin B
    13. Ganciclovir
    14. Ribavirin
  3. Loop Diuretics (especially at high dose with rapid infusion)
    1. Ethacrynic Acid
    2. Furosemide (Lasix)
  4. Antineoplastic
    1. Cisplatin
    2. Vincristine and other Vinca Alkaloids
    3. Nitrogen Mustard
    4. Methotrexate
    5. Etoposide
    6. Protein kinase inhibitor
  5. Other medications
    1. Quinine
    2. Chloroquine
    3. Sildenafil (Viagra)
    4. Caffeine
    5. Atorvastatin (Lipitor)
    6. Bupropion (Wellbutrin)
    7. Risedronate (Actonel)
    8. Verenicline (Chantix)
  1. Heavy metal Poisoning
    1. Mercury Poisoning
    2. Lead Poisoning
  2. Occupational exposures
    1. Toluene
    2. Styrene
  3. Ilicit Drugs
    1. Ecstasy