II. Causes: Common (represents 90% of Chronic Cough Causes)

  1. Post-nasal drainage (40%)
    1. Sinusitis
    2. Allergic Rhinitis
  2. Asthma (24%)
  3. Gastroesophageal Reflux (15%)
  4. Bronchitis or post-Bronchitic Cough (11%)
  5. Chronic Bronchitis
  6. Tobacco abuse
  7. Transient airway hyperresponsiveness
    1. Post-viral cough
    2. Post-Bronchitic cough
  8. Medication related
    1. ACE Inhibitors (5-20% of patients)
    2. Beta Blockers (less common)
  9. Infection or post-infectious cough
    1. Bordetella pertussis infection
      1. Pertussis is responsible for 20% of severe cough in adults and teens >2 weeks presenting to emergency departments
      2. Senzilet (2001) Clin Infect Dis 32:1691-7 [PubMed]
    2. Post-Bronchitic cough

III. Causes: Less Common Causes of Chronic Cough

  1. Congestive Heart Failure
  2. Cancer
    1. Bronchogenic Carcinoma
    2. Esophageal Cancer
  3. Lung disease
    1. Emphysema
    2. Sarcoidosis
    3. Bronchiectasis (4%)
    4. Eosinophilic Bronchitis
    5. Tuberculosis
    6. Fungal Lung Infection
    7. Cystic Fibrosis
  4. Recurrent Aspiration
    1. Post-Cerebrovascular Accident
    2. Frequent Vomiting
    3. Alcoholism
  5. Pressure from an intrathoracic mass
    1. Thoracic aneurysm
    2. Thyromegaly
    3. Mediastinal Lymphadenopathy
  6. Irritation of cough receptors in ear
    1. Impacted cerumen or hair in ear canal
    2. Hair
    3. Ear Foreign Body
  7. Opportunistic infections (immunocompromised patient)
  8. Lymphangitis carcinomatosis
  9. Foreign body
  10. Chronic occupational inhalation Bronchial irritants
  11. Psychogenic cough (Habit Cough)
  12. Arteriovenous malformation

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