II. Background

  1. Drug resistance emerges rapidly
    1. Must be used with other antituberculous drugs

III. Indications

  1. Multi-drug Tuberculosis Treatment regimen

IV. Dosing

  1. Adult: 15-25 mg/kg PO
  2. Pediatric: 15-25mg/kg PO

VI. Monitoring

  1. Baseline
    1. Serum Creatinine
    2. Visual acquity
    3. Color perception
  2. Periodic re-testing
    1. Visual acquity
    2. Color perception

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Cost: Medications

ethambutol (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
ETHAMBUTOL HCL 400 MG TABLET Generic $1.04 each

Ontology: Ethambutol (C0014964)

Definition (NCI) An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth.
Definition (MSH) An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
Definition (CSP) antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus; it may also inhibit the synthesis of spermidine in mycobacteria.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D004977
SnomedCT 24450004, 387129004
LNC LP15625-4, MTHU008452
English Ethambutol, ethambutol, 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (S-(R*,R*))-, Ethambutol [Chemical/Ingredient], ETHAMBUTOL, Ethambutolol, Ethambutol (product), Ethambutol (substance)
Swedish Etambutol
Czech ethambutol
Finnish Etambutoli
Russian ETAMBUTOL, ЭТАМБУТОЛ
Japanese 塩酸エタンブトール, エタンブトール
Polish Etambutol
Spanish etambutol (producto), etambutol (sustancia), etambutol, Etambutol
French Éthambutol
German Ethambutol
Italian Etambutolo
Portuguese Etambutol