Urology Book

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Interstitial Brachytherapy for Prostate Cancer

Aka: Interstitial Brachytherapy for Prostate Cancer, Prostate Seed Implant Radiotherapy
  1. Indications
    1. Localized Prostate Cancer (Stages A to C)
  2. Technique
    1. Permanent radioactive seed implants into Prostate
      1. Iodine 125
      2. Palladium 103
    2. Seeds precisely geometric arranged by computer
  3. Efficacy
    1. Appears effective as conventional Prostate Radiotherapy
  4. Advantages over External Beam Prostate Radiotherapy
    1. Higher radiation dose with less adverse effects
    2. Avert daily Radiation Therapy for 4 to 6 weeks
  5. Adverse Effects
    1. Acute irritative uropathy for first 3 months
      1. Urinary urgency
      2. Dysuria and Pelvic Pain
      3. Urinary frequency
    2. Urinary Incontinence (1%)
    3. Impotence (30 to 50%)
    4. Rectal irritation (3 to 10%)
      1. Diarrhea
      2. Stool Urgency
      3. Tenesmus
      4. Rectal Bleeding
  6. References
    1. Middleton (1996) CA Cancer J Clin 46(4):249-53 [PubMed]
    2. Naitoh (1998) Am Fam Physician 57(7):1531-9 [PubMed]
    3. Narayan (April, 1996) Hospital Physician, p.37-50
    4. Porter (1995) CA Cancer J Clin 45(3):165-78 [PubMed]
    5. Williams (1996) Postgrad Med 100(3): 105-20 [PubMed]

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