Urology Book

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Viagra

Aka: Viagra, Sildenafil
  1. Indications
    1. Psychogenic Impotence
    2. Neurogenic Impotence
    3. Vasculogenic Impotence
  2. Pharmacokinetics
    1. Onset 30-60 minutes
    2. Duration: 4-5 hours
    3. Peak: 1 hour if taken while Fasting
      1. Peak delayed by 1 hour if taken with fatty meal
    4. Half Life: 4 hours
    5. Metabolized by Liver and excreted mostly in stool
      1. Clearance delayed in age over 65 years
      2. Clearance delayed in Liver disease
  3. Dosing
    1. Start 50 mg PO 1 hour before intercourse
      1. Do not take more than once per day
      2. Most insurance limits to 6 per month
    2. Indications to start with half dosing (25 mg)
      1. Age over 65 years
      2. Hepatic Impairment
      3. Renal Impairment
    3. Consider crushing tablet and placing under Tongue
      1. May increase onset of action to 15 minutes
      2. May also increase absorption
        1. Consider lowering dose
  4. Cost
    1. Wholesale: $7 per pill
  5. Contraindications
    1. See Phosphodiesterase Inhibitors (PDE5)
    2. Men using nitrates (causes profound Hypotension)
    3. Men using alpha blockers (e.g. Hytrin for BPH)
  6. Mechanism
    1. See Phosphodiesterase Inhibitors (PDE5)
  7. Drug Interactions
    1. See Phosphodiesterase Inhibitors (PDE5)
    2. Profound Vasodilitation and Hypotension with Nitroglycerin and alpha blockers such as Prazosin (Avoid)
    3. Cytochrome P3A4 related interactions (Cimetidine, systemic Antifungals, Protease Inhibitors and Macrolides
  8. Adverse Effects: Viagra (but most apply to the PDE5 Class as a whole)
    1. See Phosphodiesterase Inhibitors (PDE5)
    2. Hypotensive effect for men on Nitrates (Avoid)
    3. Vision effects (color vision, Vision Loss)
    4. Sensorineural Hearing Loss
    5. Mild Headache
  9. Reference
    1. Boolell (1996) Br J Urol 78:257-61 [PubMed]
    2. Cheitlin (1999) J Am Coll Cardiol 33:273-82 [PubMed]
    3. (1998) Med Lett Drugs Ther 40(1026):51-2 [PubMed]
    4. Rendell (1999) JAMA 281(5): 421-26 [PubMed]
Medication Costs
viagra (on 6/1/2017 at Medicaid.Gov Pharmacy Drug pricing)
VIAGRA 100 MG TABLET $59.10 each
VIAGRA 25 MG TABLET $59.30 each
VIAGRA 50 MG TABLET $58.73 each
sildenafil (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
SILDENAFIL 20 MG TABLET Generic $0.33 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

sildenafil (C0529793)

Definition (CHV) a drug for male impotence
Definition (NCI_NCI-GLOSS) A drug used to treat erectile dysfunction. Sildenafil relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase inhibitor.
Definition (PDQ) The citrate salt of a pyrazolopyrimidinone derivative structurally related to zaprinast. Sildenafil selectively inhibits cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase, resulting in vasodilation in the corpus cavernosum of the penis and penile erection. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269137&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=269137&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26670" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C101426
SnomedCT 109123009, 372572000
English sildenafil, sildenafil [Chemical/Ingredient], SILDENAFIL, Sildenafil, Sildenafil (product), Sildenafil (substance)
Spanish sildenafilo, sildenafil, sildenafilo (producto), sildenafil (producto), sildenafilo (sustancia), sildenafil (sustancia)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Viagra (C0663448)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C101426
English Viagra, Abbott brand of sildenafil citrate, Pfizer brand 1 of sildenafil citrate
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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