Urology Book

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Levitra

Aka: Levitra, Verdenafil
  1. Dosing
    1. Standard Dose: 5-20 mg up to once daily, 1 hour prior to intercourse
    2. Adjusted maximum dosing
      1. Hepatic insufficiency: 10 mg
      2. Age over 65 years: 5 mg
  2. Pharmacokinetics
    1. Onset 30-60 minutes
    2. Duration: 4-5 hours
  3. Contraindications
    1. See Phosphodiesterase Inhibitors (PDE5)
    2. Men using nitrates (causes profound Hypotension)
    3. Men using alpha blockers (e.g. Hytrin for BPH)
  4. Mechanism
    1. See Phosphodiesterase Inhibitors (PDE5)
  5. Drug Interactions
    1. See Phosphodiesterase Inhibitors (PDE5)
    2. Profound Vasodilitation and Hypotension with Nitroglycerin and alpha blockers such as Prazosin (Avoid)
    3. Cytochrome P3A4 related interactions (Cimetidine, systemic Antifungals, Protease Inhibitors and Macrolides
  6. Adverse Effects: Viagra (but most apply to the PDE5 Class as a whole)
    1. See Phosphodiesterase Inhibitors (PDE5)
    2. Hypotensive effect for men on Nitrates (Avoid)
    3. Vision effects (color vision, Vision Loss)
    4. Sensorineural Hearing Loss
    5. Mild Headache
Medication Costs
levitra (on 1/1/2017 at Medicaid.Gov Pharmacy Drug pricing)
LEVITRA 10 MG TABLET $47.13 each
LEVITRA 20 MG TABLET $46.75 each
LEVITRA 5 MG TABLET $48.16 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

vardenafil (C0971579)

Definition (NCI) A benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, prolonging penile erection.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C426063
SnomedCT 407979001, 404858007
LNC LP100060-5, MTHU035877
English vardenafil [Chemical/Ingredient], 1-(((3-(3,4-dihydro-5-methyl)-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine, vardenafil, VARDENAFIL, Vardenafil (product), Vardenafil (substance), Vardenafil
Spanish vardenafil (producto), vardenafil (sustancia), vardenafil
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Levitra (C1174890)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C426063
English Levitra, levitra, Bayer brand of vardenafil hydrochloride
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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