Urology Book

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Apomorphine

Aka: Apomorphine, Uprima
  1. Mechanism
    1. Central acting, Dopaminergic agonist
  2. Pharmacokinetics
    1. Onset: 10 minutes
    2. Duration: 30 minutes
  3. Dose
    1. Uprima 2 to 6 mg SL
  4. Efficacy
    1. Effective in 55 to 60% of men (contrast 32% in Placebo)
  5. Adverse Effects (58% of men on 6 mg)
    1. Nausea (39%)
    2. Vomiting (10%)
    3. Dizziness (20%)
    4. Somnolence (11%)
    5. Sweaty (18%)
    6. Hypotension (4%)
    7. Syncope (2%)

Apomorphine (C0003596)

Definition (MSH) A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.
Definition (CSP) derivative of morphine that is a dopamine D2 agonist; a powerful emetic useful in acute poisoning; has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D001058
SnomedCT 387375001, 67939000
English Apomorphine, 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (R)-, Apomorphine [Chemical/Ingredient], APOMORPHINE, Apomorphine (product), Apomorphine (substance), apomorphine
Swedish Apomorfin
Czech apomorfin
Finnish Apomorfiini
Russian APOMORFIN, АПОМОРФИН
Polish Apomorfina
Japanese アポモルフィン, アパフィナム, 塩酸アポモルヒネ, アポモルヒネ
Spanish apomorfina (producto), apomorfina (sustancia), apomorfina, Apomorfina
French Apomorphine
German Apomorphin
Italian Apomorfina
Portuguese Apomorfina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Uprima (C1657321)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
English Uprima
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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