Urology Book

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Sulfosalicylic Acid Test

Aka: Sulfosalicylic Acid Test, Protein Precipitation Test
  1. See Also
    1. Urinalysis
    2. Urine Protein
  2. Indication
    1. Confirmation of proteiunuria on Urine Protein dipstick
    2. Replaced with Urine Protein to Creatinine Ratio
  3. Efficacy
    1. Highly sensitive for Urine Protein
    2. Detects light chain proteins
  4. Technique
    1. Urine mixed with 20% Sulfosalicylic Acid (SSA)
    2. Variation in results may be as much as 20%
    3. Urine turbidity measured with photometer (increased turbidity with precipitated protein)
      1. Turbidity reported as trace to 4+
  5. Interpretation: Positive Test
    1. See Proteinuria
  6. Interpretation: False positive causes
    1. Radiographic contrast agents (in last 3 days)
    2. Tolbutamide
    3. Penicillins
    4. Sulfisoxazole
  7. Interpretation: Negative Test
    1. False Proteinuria
    2. Renal Tubules not reabsorbing

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