Urology Book

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Penile Cancer

Aka: Penile Cancer, Invasive Squamous Cell Carcinoma of the Penis
  1. Epidemiology
    1. Prevalence: 2-3 per 100,000 (rare)
    2. Incidence: Peaks over age 70 years
  2. Pathophysiology
    1. Squamous Cell Carcinoma accounts for 95% of Penile Cancers
  3. Risk Factors
    1. Foreskin (Penile Cancer is almost exclusive to uncircumcised men)
    2. Human Papillomavirus Infection (HPV)
    3. Penile Lichen Sclerosus
    4. Tobacco abuse
    5. Poor foreskin hygiene
    6. Phimosis
  4. Signs
    1. Delay in presentation is common (average delay >6 months from onset)
    2. Early presentation
      1. Painless lump or penile ulvcer
    3. Later presentation
      1. Thickened skin and wart-like Penile Growth
      2. Foul discharge may be present
      3. Large exophytic irregular masses may develop
  5. Differential Diagnosis
    1. Giant condyloma
  6. Labs: Biopsy
    1. Biopsy all suspicious lesions
  7. Management
    1. Early stage Penile Cancer may be treated in similar fashion to Penile Cancer in Situ
    2. Higher stage Penile Cancer (T2 to T4) requires penile amputation for cure
  8. References
    1. Mosconi (2005) Crit Rev Oncol Hematol 53(2): 165-77 [PubMed]
    2. Teichman (2010) Am Fam Physician 81(2): 167-74 [PubMed]

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