Surgery Book

http://www.fpnotebook.com/

Propofol Infusion Syndrome

Aka: Propofol Infusion Syndrome
  1. See Also
    1. Propofol
    2. Fospropofol
  2. Epidemiology
    1. ICU patients (most common)
    2. Patients on Backboard in Emergency Department
    3. Children more often affected
  3. Risk Factors
    1. Children
    2. Infusion dose >3-4 mg/kg/hour
    3. Infusion duration >12-24 hours
    4. Risk may be increased in patients with underlying mitochondrial disorders or muscle disorders
  4. Pathophysiology
    1. Propofol infusion results in mitochondrial respiration arrest (similar to cyanide Poisoning)
  5. Risk Factors
    1. Young patients
    2. Sepsis
    3. Concurrent pressor or glucocorticoid administration
  6. Signs
    1. Metabolic Acidosis
    2. Lactic Acidosis
    3. Rhabdomyolysis
    4. Dysrhythmias
      1. Bradycardia
      2. Ventricular Tachycardia
      3. Asystole
  7. Management
    1. Supportive care
    2. Hemodialysis if Acute Renal Failure occurs
  8. Prognosis
    1. High mortality rate
  9. References
    1. Majoewsky (2012) EM:RAP 12(1): 3

Propofol infusion syndrome (C1328409)

Concepts Finding (T033)
Italian Sindrome da infusione di propofol
Japanese プロポフォール注入症候群, プロポフォールチュウニュウショウコウグン
Czech Syndrom po infuzi propofolu
Hungarian Propofol infusio syndroma
English Propofol infusion syndrome
Portuguese Síndrome de infusão de propofol
Spanish Síndrome de infusión con propofol
Dutch propofolinfuussyndroom
French Syndrome lié à une perfusion de propofol
German Propofol-Infusions-Syndrom
Sources
Derived from the NIH UMLS (Unified Medical Language System)


You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree