Surgery Book

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Fospropofol

Aka: Fospropofol, Lusedra
  1. See Also
    1. Propofol
  2. Dosing: Deep Sedation in Adults
    1. Weight-based adjustment
      1. Weight over 90 kg: Dose at 90 kg
      2. Weight under 60 kg: Dose at 60 kg
    2. Age under 65 years old
      1. Starting dose: 6.5 mg/kg (up to 16.5 ml max)
      2. Supplemental dose: 1.6 mg/kg IV every 4 minutes (up to 4 ml max)
    3. Age 65 years and older (or severe systemic disease)
      1. Dose at 75% of that listed above
  3. Mechanism
    1. Activity is same as Propofol once metabolized
    2. Prodrug for Propofol
      1. Metabolized to Propofol by Alkaline Phosphatase
      2. Equivalence to Propofol is 1 mmol to 1 mmol
    3. Drug Abuse potential
      1. Schedule IV Drug
      2. Clear liquid that can be mixed with water
      3. Orally absorbed
      4. Onset of action is 4 minutes delayed beyond onset of Propofol (due to metabolism step)
      5. Reference
        1. Majoewsky (2012) EM:RAP 12(1): 3
  4. Adverse Effects
    1. Same as Propofol

fospropofol (C2370726)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C472965
English Fospropofol, fospropofol, FOSPROPOFOL
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Lusedra (C2370730)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C472965
English Lusedra, Eisai Inc. Brand of fospropofol disodium
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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