Rheumatology Book

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TNF Inhibitor

Aka: TNF Inhibitor, Anti-TNF Agent, Tumor Necrosis Factor Inhibitor
  1. Indications: Autoimmune Conditions
    1. Rheumatoid Arthriitis
    2. Spondyloarthropathy (e.g. Ankylosing Spondylitis)
    3. Inflammatory Bowel Disease
    4. Psoriasis
  2. Preparations
    1. Older xTNF agents included Thalidomide
    2. Modern xTNF agents (in 2016) are primarily monoclonal antibodies
      1. Examples include Infliximab (Remicade), Adalimumab (Humira) and Etanercept (Enbrel)
  3. Complications
    1. Nonmelanoma Skin Cancer
    2. Opportunistic Infection or reactivated infections
      1. Tuberculosis
        1. Screen for latent infection prior to initiating TNF agent
      2. Disseminated Histoplasmosis
      3. Coccidioidomycosis
      4. Blastomycosis
      5. Hepatitis B
      6. Cytomegalovirus
      7. Leishmaniasis
    3. References
      1. Toussi (2013) Clin Infect Dis 57:1318–30 +PMID:23899685 [PubMed]

Anti-tumor necrosis factor alpha drug (C1562242)

Concepts Pharmacologic Substance (T121)
SnomedCT 420693002, 416897008
English Anti-tumor necrosis factor alpha agent (substance), Anti-tumor necrosis factor alpha agent, Anti-tumour necrosis factor alpha agent, Anti-TNF drug, Anti-tumor necrosis factor alpha drug (product), Anti-tumor necrosis factor alpha drug, Anti-tumour necrosis factor alpha drug
Spanish agente con anti-factor de necrosis tumoral alfa (sustancia), agente con FNT-alfa, agente con TNF-alfa, agente con anti-factor de necrosis tumoral alfa, factor de necrosis tumoral alfa (producto), factor de necrosis tumoral alfa
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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