Rheumatology Book

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Anti-Topoisomerase I Antibody

Aka: Anti-Topoisomerase I Antibody, Anti-Scl-70 Antibody, Anti-Topoisomerase I, Anti-DNA-Topoisomerase I, Anti-Scl-70
  1. See Also
    1. Antinuclear Antibody
  2. Negative
    1. Normal
  3. Positive (Percentage refers to sensitivity)
    1. Scleroderma (20-30% sensitivity)
      1. Anti-Scl-70 is highly specific for Scleroderma
      2. Implies a poor prognosis
    2. Associated with renal involvement
  4. References
    1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
    2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
    3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
    4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

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