Rheumatology Book

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Anti-Double Stranded DNA Antibody

Aka: Anti-Double Stranded DNA Antibody, Anti-dsDNA Antibody, Double Stranded DNA Antibody, Anti-dsDNA
  1. See Also
    1. Antinuclear Antibody
  2. Indication
    1. Highly specific for Systemic Lupus Erythematosus
  3. Normal
    1. Negative
  4. Positive (percentage refers to sensitivity)
    1. Systemic Lupus Erythematosus (60%)
      1. Associated with Lupus Nephritis
      2. Associated with Lupus CNS Involvement
      3. Correlates with disease activity
    2. Sjogren's Syndrome (5%)
    3. Rheumatoid Arthritis (<5%)
    4. Chronic active hepatitis
    5. Biliary Cirrhosis
    6. Epstein Barr Virus
    7. Cytomegalovirus
  5. References
    1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
    2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
    3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
    4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

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